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The Duplex Interaction of Microbiome with Chemoradiation and Immunotherapy: Potential Implications for Colorectal Cancer

  • Azhar Saeed
  • Fariha Eshrat
  • Shahid Umar
  • Anwaar SaeedEmail author
Basic Science Foundations in Colorectal Cancer (S Umar, Section Editor)
  • 11 Downloads
Part of the following topical collections:
  1. Topical Collection on Basic Science Foundations in Colorectal Cancer

Abstract

Purpose of review

Gut microbiota has the ability to modify the metabolism of wide array of therapeutic drugs. Current treatment modalities used in colorectal cancer have a narrow therapeutic index with a side effects profile that decreases tolerance to these treatments and adversely affects treatment outcome. Harnessing the gut microbiota ability to modify oncotherapeutic drugs metabolism and hence efficacy, could be potentially used to improve treatment outcomes in colorectal cancer patients. This review will shed lights on important findings from recent microbiome interaction studies which would hopefully serve as a useful tool to guide future translative colorectal cancer research.

Recent findings

Recent advances in microbiome studies have revealed an interesting aspect of gut microbes’ carcinogenic properties in dysbiotic gut environment. Microbiota niche in colorectal cancer can also modify efficacy and toxicity profile of different oncotherapeutic treatment modalities from chemoradiotherapy to immunotherapy. Conversely, each of these treatment modalities has numerous effects on the gastrointestinal flora, causing changes in the gut microbial community that affects host morbidity and mortality.

Summary

Symbiotic gut microbiota is an incredible functioning organ that maintains essential aspects of our homeostasis and immunity. According to the recent body of literature, they also can modify efficacy of many therapeutic drugs including oncotherapy. Considering that unexplainable variable treatment outcomes as well as variable tolerance to treatment have been observed in colorectal cancer patients, studying gut microbiota modulatory effects on oncotherapy might be a feasible approach to explain this phenomenon.

Keywords

Chemotherapy Radiotherapy Chemoradiation Cancer Oncology Colon Microbiome Microbiota Pharmacomicrobiomics Gastrointestinal Oncotherapy 

Notes

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

References

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Azhar Saeed
    • 1
  • Fariha Eshrat
    • 2
  • Shahid Umar
    • 3
  • Anwaar Saeed
    • 2
    Email author
  1. 1.Department of Pathology and Laboratory MedicineKansas University Medical CenterWestwoodUSA
  2. 2.Department of Medicine, Division of Medical OncologyKansas University Cancer CenterWestwoodUSA
  3. 3.Department of General SurgeryKansas University Medical CenterWestwoodUSA

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