Current Colorectal Cancer Reports

, Volume 11, Issue 6, pp 298–302 | Cite as

FIRE-3 and C80405: Is There a Best Choice for Initial Treatment of Metastatic Colorectal Cancer?

  • Jan Van den BrandeEmail author
  • Kostas Papadimitriou
  • Marika Rasschaert
  • Marc Peeters
Adjuvant Therapy for Colon Cancers (AB Benson III and A de Gramont, Section Editors)
Part of the following topical collections:
  1. Topical Collection on Adjuvant Therapy for Colon Cancers


In the treatment of metastatic colorectal cancer, chemotherapy is used as a backbone to which an angiogenesis inhibitor such as bevacizumab (vascular endothelial growth factor [VEGF]) or a monoclonal antibody to the epidermal growth factor receptor (EGFR) such as cetuximab or panitumumab is added. In this article, we seek answers to the question: “FIRE-3 and C80405: is there a best choice for initial treatment of metastatic colorectal cancer?” In the absence of clear and univocal evidence that EGFR inhibitors should be used in the first-line setting for patients with metastatic RAS wild-type colorectal cancer, the physician and patient still have the choice between bevacizumab or an EGFR inhibitor as addition to the chemotherapy (FOLFIRI or FOLFOX) in this setting. This choice will be influenced by the different toxicity profiles of bevacizumab and cetuximab or panitumumab and will therefore depend on existing comorbidities of the patient and patient/physician preferences. The higher response rate of the combination of chemotherapy with cetuximab could make this treatment more interesting as induction therapy.


Metastatic colorectal cancer Cetuximab Bevacizumab FOLFIRI FOLFOX KRAS RAS Exon 2 Panitumumab 


Compliance with Ethics Guidelines

Conflict of Interest

Jan Van den Brande, Kostas Papadimitriou, Marika Rasschaert and Marc Peeters declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Jan Van den Brande
    • 1
    Email author
  • Kostas Papadimitriou
    • 1
  • Marika Rasschaert
    • 1
  • Marc Peeters
    • 1
  1. 1.Department of Medical OncologyAntwerp University HospitalEdegemBelgium

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