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Current Colorectal Cancer Reports

, Volume 8, Issue 4, pp 254–262 | Cite as

The Epigenetics of Gastrointestinal Malignancies

  • Zainul Hasanali
  • August Stuart
  • Nelson Yee
  • Kamal Sharma
  • Elliot EpnerEmail author
Translational Colorectal Oncology (Y Jiang, Section Editor)

Abstract

Gastrointestinal malignancies, including colorectal cancer (CRC), pancreatic cancer, and esophageal cancer, have been classically seen as genetic diseases, involving mutations and/or deletions in oncogenes and tumor suppressor genes. Recent evidence demonstrates that epigenetic changes coexist with these genetic changes and contribute to the malignant phenotype. This review will focus on epigenetic dysregulation in gastrointestinal malignancies involving multiple mechanisms of epigenetic control. Interactions between studied epigenetic alterations and genetic alterations are common.

Keywords

Gastrointestinal cancer Epigenetics Cladribine Vorinostat Cetuximab DNA methylation Histone acetylation Colorectal Pancreatic 

Notes

Acknowledgments

E. Epner is supported by grants from Merck and Takeda.

Disclosure

Z. Hasanali, none; A. Stuart, none; N.S.-S. Yee, none; K. Sharma, payment for lectures (including service on speakers bureaus) from Allos Therapeutics and Millennium Pharmaceuticals; E. Epner, payment for lectures (including service on speakers bureaus) from Celgene, Novartis, Enzon Pharmaceuticals, GlaxoSmithKline (GSK), and Incyte Corporation.

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Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  • Zainul Hasanali
    • 1
  • August Stuart
    • 1
  • Nelson Yee
    • 2
  • Kamal Sharma
    • 3
  • Elliot Epner
    • 4
    Email author
  1. 1.Penn State Hershey Cancer InstituteHersheyUSA
  2. 2.Penn State Hershey Cancer InstituteDivision of Hematology/OncologyHersheyUSA
  3. 3.Penn State Hershey Cancer InstituteHersheyUSA
  4. 4.Penn State Hershey Cancer InstituteDivision of Hematology/OncologyHersheyUSA

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