Current Colorectal Cancer Reports

, Volume 8, Issue 3, pp 225–231

Gene Signatures in Stage II Colon Cancer: A Clinical Review

Adjuvant Therapy for Colon Cancers (AB Benson and A de Gramont, Section Editors)


Understanding the biology of cancer is the key to understanding its behavior. Stage II colon cancers represent a unique treatment challenge for medical oncologists because they contain a very heterogeneous group of tumors with a wide range of recurrence risks after resection. Defining these differences in biology can help to explain differences in disease behavior. To this end, gene signatures have been developed to define various prognostic groups beyond the clinicopathologic features alone. Adjuvant chemotherapy for stage II colon cancers as a group has not shown survival advantage in clinical trials. Future research to develop gene signatures to predict a group that will benefit from adjuvant chemotherapy will be helpful in the clinical decision-making process. The purpose of this review is to present the prognostic gene signatures currently available for use, those in development, and their utility in stratifying recurrence risk in stage II colon cancer patients.


Colon cancer Stage II Gene signatures Prognostic score Recurrence score Predictive score Oncotype DX RS ColoPrint ColDx MSI Guanylyl cyclase C Adjuvant! Online Numeracy 

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.National Surgical Adjuvant Breast and Bowel Project (NSABP)Four Allegheny CenterPittsburghUSA
  2. 2.Allegheny Cancer Center at Allegheny General HospitalPittsburghUSA

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