Current Colorectal Cancer Reports

, Volume 7, Issue 3, pp 241–245 | Cite as

Reduced Chemotherapy Duration: A Good Idea?

  • Joleen Hubbard
  • Axel Grothey


Over the past three decades, survival outcomes of high-risk stage II and stage III colon cancer have improved with the use of adjuvant chemotherapy. Oxaliplatin and fluoropyrimidine combination regimens, given for 6 months, are the current standard of care. However, chronic peripheral neuropathy can result as a side effect of oxaliplatin use. Investigators have questioned whether the recommended duration of adjuvant therapy is necessary. This review discusses the history of adjuvant therapy for colon cancer and provides a rationale for an ongoing clinical trial collaboration addressing the optimal duration of adjuvant therapy.


Colon cancer Adjuvant therapy 5-fluorouracil Oxaliplatin Chemotherapy-induced sensory neuropathy Peripheral neuropathy 



No potential conflicts of interest relevant to this article were reported.


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Division of Medical OncologyMayo ClinicRochesterUSA

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