Current Colorectal Cancer Reports

, Volume 6, Issue 4, pp 199–205

Management Strategies for Patients with KRAS Mutations

  • Stephen Leong
  • S. Gail Eckhardt
  • Wells A. Messersmith


In an era of targeted therapies and personalized medicine, the search for predictive and prognostic biomarkers has reached the forefront in cancer research. Testing for KRAS mutation status in the treatment of colorectal cancer (CRC) has now become standard of care, especially for patients being considered for treatment with antibodies to the epidermal growth factor receptor (EGFR). Because metastatic CRC patients whose tumors harbor KRAS mutations do not respond to EGFR-targeting antibodies, their management is challenging. As our understanding of the role of KRAS mutations grows, new treatment strategies are being devised but are not yet ready for clinical use. In this review, we examine some of these potential strategies.


KRAS KRAS mutations Colorectal cancer Novel therapeutics 


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Stephen Leong
    • 1
  • S. Gail Eckhardt
    • 1
  • Wells A. Messersmith
    • 1
  1. 1.Gastrointestinal Malignancies and Developmental Therapeutics Program, Division of Medical OncologyUniversity of Colorado Cancer CenterAuroraUSA

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