Colorectal cancer prevention: Diet, drugs, or nothing
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Colorectal cancer (CRC), one of the leading causes of cancer death worldwide, is now considered the most preventable malignancy. Although an estimated 145,290 Americans were diagnosed and approximately 56,290 died of the disease, CRC death could be prevented in 28,145 cases if the American Cancer Society’s screening recommendations were followed. By virtue of endoscopic and imaging accessibility of the colorectum, along with its well-characterized pathogenesis, CRC prevention and early detection have become a reality that could significantly diminish death and suffering from cancer. Unfortunately, widespread application of current screening technologies has been difficult; progress continues as visualization of and access to the colorectum enable researchers to evaluate the activity of dietary changes, nutritional supplementation, and chemoprevention agents on genetic, molecular, and histologic colorectal carcinogenesis.
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