Harnessing Cardiac Regeneration as a Potential Therapeutic Strategy for AL Cardiac Amyloidosis

  • Shaurya Joshi
  • Alessandro Evangelisti
  • Ronglih Liao
  • Kevin M. AlexanderEmail author
Regenerative Medicine (SM Wu, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Regenerative Medicine


Purpose of Review

Cardiac regeneration has received much attention as a possible means to treat various forms of cardiac injury. This review will explore the field of cardiac regeneration by highlighting the existing animal models, describing the involved molecular pathways, and discussing attempts to harness cardiac regeneration to treat cardiomyopathies.

Recent Findings

Light chain cardiac amyloidosis is a degenerative disease characterized by progressive heart failure due to amyloid fibril deposition and light chain–mediated cardiotoxicity. Recent findings in a zebrafish model of light chain amyloidosis suggest that cardiac regenerative confers a protective effect against this disease.


Cardiac regeneration remains an intriguing potential tool for treating cardiovascular disease. Degenerative diseases, such as light chain cardiac amyloidosis, may be particularly suited for therapeutic interventions that target cardiac regeneration. Further studies are needed to translate preclinical findings for cardiac regeneration into effective therapies.


Amyloidosis Light chain Cardiac regeneration Cardiomyopathy Zebrafish 


Funding Information

Dr. Liao is supported by the National Institutes of Health (R01 grants HL 128135 and HL 132511). Dr. Alexander is supported the American Heart Association-Amos Medical Faculty Development Program.

Compliance with Ethical Standards

Conflict of Interest

Shaurya Joshi, Alessandro Evangelisti, and Ronglih Liao declare that they have no conflict of interest. Kevin Alexander has received a grant from Pfizer and participated on advisory boards for Alnylam and Eidos.

Human and Animal Rights and Informed Consent

The article does not contain any studies with human or animal subjects performed by any of the authors.


All authors take responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2020

Authors and Affiliations

  • Shaurya Joshi
    • 1
  • Alessandro Evangelisti
    • 2
    • 3
  • Ronglih Liao
    • 2
    • 3
  • Kevin M. Alexander
    • 2
    • 3
    Email author
  1. 1.Division of Genetics, Department of Medicine, Brigham and Women’s HospitalHarvard Medical SchoolBostonUSA
  2. 2.Stanford Cardiovascular InstituteStanford University School of MedicineStanfordUSA
  3. 3.Stanford Amyloid Center, Division of Cardiovascular MedicineStanford University School of MedicinePalo AltoUSA

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