Current Cardiology Reports

, 21:148 | Cite as

Endomyocardial Fibrosis: an Update After 70 Years

  • Ana Olga MocumbiEmail author
  • J. Russell Stothard
  • Paulo Correia-de-Sá
  • Magdi Yacoub
Global Cardiovascular Health (GY Bukhman, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Global Cardiovascular Health


Purpose of Review

This review aims at highlighting the need to better understand the pathogenesis and natural history of endomyocardial fibrosis when set against its changing endemicity and disease burden, improvements in diagnosis, and new options for clinical management.

Recent Findings

Progress in imaging diagnostic techniques and availability of new targets for drug and surgical treatment of heart failure are contributing to earlier diagnosis and may lead to improvement in patient survival.


Endomyocardial fibrosis was first described in Uganda by Davies more than 70 years ago (1948). Despite its poor prognosis, the etiology of this neglected tropical restrictive cardiomyopathy still remains enigmatic nowadays. Our review reflects on the journey of scientific discovery and construction of the current guiding concepts on this mysterious and fascinating condition, bringing to light the contemporary knowledge acquired over these years. Here we describe novel tools for diagnosis, give an overview of the improvement in clinical management, and finally, suggest research themes that can help improve patient outcomes focusing (whenever possible) on novel players coming into action.


Endomyocardial fibrosis Inflammation Neglected cardiovascular disease 


Compliance with Ethical Standards

Conflict of Interest

Ana Mocumbi, J. Russell Stothard, Paulo Correia-de-Sá, and Magdi Yacoub declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: •• Of major importance

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Ana Olga Mocumbi
    • 1
    • 2
    Email author
  • J. Russell Stothard
    • 3
  • Paulo Correia-de-Sá
    • 4
    • 5
  • Magdi Yacoub
    • 6
    • 7
  1. 1.Division of Non-Communicable DiseasesUniversidade Eduardo Mondlane, Faculdade de MedicinaMaputoMozambique
  2. 2.Instituto Nacional de SaúdeMarracueneMozambique
  3. 3.Liverpool School of Tropical MedicineLiverpoolUK
  4. 4.Centro de Investigação Farmacológica e Inovação MedicamentosaPortoPortugal
  5. 5.Instituto de Ciências Biomédicas de Abel Salazar (ICBAS)Universidade do PortoPortoPortugal
  6. 6.Imperial College LondonLondonUK
  7. 7.Aswan Heart CentreAswanEgypt

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