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Cannabis Use as a Risk Factor for Takotsubo (Stress) Cardiomyopathy: Exploring the Evidence from Brain-Heart Link

  • Myocardial Disease (A Abbate and G Sinagra, Section Editors)
  • Published:
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Abstract

Purpose of Review

Recently, an association between cannabis use and Takotsubo (stress) cardiomyopathy (TTC) has been shown. With the current trend of legalization of cannabis, it is important to understand brain effects of cannabis use that could lead to cardiac disease, such as TTC. Here we review recent brain imaging studies in order to search for the evidence supporting the association between cannabis use, stress, and TTC.

Recent Findings

There exist brain imaging studies showing similar findings across TTC, stress, and cannabis use. These similar findings are mainly centered on a key central autonomic network region amygdala, i.e., amygdala hyperactivity/hyperconnectivity when exposed to challenge, stress, or negative stimuli.

Summary

This similarity supports a close association among cannabis use, stress, and TTC. Amygdala-centered neuronal circuits could underlie cannabis use as risk factor to TTC. Based on the findings, several directions for future studies are proposed.

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Authors and Affiliations

  1. Institute for Drug and Alcohol Studies, Virginia Commonwealth University (VCU), 203 East Cary Street, Suite 202, Richmond, VA, 23219, USA

    Liangsuo Ma & F. Gerard Moeller

  2. Department of Radiology, Virginia Commonwealth University (VCU), 203 East Cary Street, Suite 202, Richmond, VA, 23219, USA

    Liangsuo Ma

  3. Pauley Heart Center, Virginia Commonwealth University (VCU), Richmond, VA, 23298, USA

    Marco Giuseppe Del Buono

  4. C. Kenneth and Dianne and Wright’ Center for Clinical and Translational Research, Virginia Commonwealth University (VCU), Richmond, VA, 23298, USA

    Marco Giuseppe Del Buono

  5. Catholic University of the Sacred Heart, Rome, Italy

    Marco Giuseppe Del Buono

  6. Department of Psychiatry, Virginia Commonwealth University (VCU), Richmond, VA, 23298, USA

    F. Gerard Moeller

  7. Department of Pharmacology and Toxicology, Virginia Commonwealth University (VCU), Richmond, VA, 23298, USA

    F. Gerard Moeller

  8. Department of Neurology, Virginia Commonwealth University (VCU), Richmond, VA, 23298, USA

    F. Gerard Moeller

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  1. Liangsuo Ma
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Ma, L., Del Buono, M.G. & Moeller, F.G. Cannabis Use as a Risk Factor for Takotsubo (Stress) Cardiomyopathy: Exploring the Evidence from Brain-Heart Link. Curr Cardiol Rep 21, 121 (2019). https://doi.org/10.1007/s11886-019-1210-0

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