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The Autonomic Nervous System and Hypertension: Ethnic Differences and Psychosocial Factors

  • LaBarron K. Hill
  • Julian F. ThayerEmail author
Psychological Aspects of Cardiovascular Diseases (A Steptoe, Section Editor)
  • 90 Downloads
Part of the following topical collections:
  1. Topical Collection on Psychological Aspects of Cardiovascular Diseases

Abstract

Purpose of the Review

In the present paper, we overview emerging research examining the autonomic nervous system (ANS), especially the parasympathetic nervous system as indexed by heart rate variability (HRV), and the impact of psychosocial factors on hypertension-related disease in African Americans.

Recent Findings

A growing corpus of studies has shown that (1) usual patterns of compensatory sympathetic-parasympathetic regulation differ between African Americans and European Americans; (2) despite their enhanced cardiovascular disease risk profile, African Americans tend to exhibit higher HRV relative to European Americans; and (3) racial discrimination and other forms of psychosocial stress are associated with diminished HRV among African Americans.

Summary

Significant disparities in hypertension-related disease exist such that African Americans have greater risk. The underlying factors associated with this increased risk are, to date, not fully understood. The present review provides evidence for a unique pattern of ANS regulation in African Americans and shows that psychosocial factors such as racial discrimination may contribute to this paradoxical situation.

Keywords

Hypertension Autonomic imbalance Heart rate variability Discrimination African Americans 

Notes

Funding Information

LaBarron K. Hill is supported by funding from the National Heart Lung and Blood Institute (#121708).

Compliance with Ethical Standards

Conflict of Interest

LaBarron K. Hill and Julian F. Thayer declare that they have no conflicts of interest.

Human and Animal Rights and Informed Consent

This article is based on published papers and does not contain any examination with human or animal subjects performed by any of the authors.

References

Papers of particular interest, published recently, have been highlighted as: • Of importance

  1. 1.
    Egan BM, Li J, Hutchison FN, Ferdinand KC. Hypertension in the United States, 1999 to 2012: progress toward Healthy eople 2020 goals. Circulation. 2014;130(19):1692–9.  https://doi.org/10.1161/CIRCULATIONAHA.114.010676.CrossRefPubMedPubMedCentralGoogle Scholar
  2. 2.
    Go AS, Mozaffarian D, Roger VL, Benjamin EJ, Berry JD, Blaha MJ, et al. Heart disease and stroke statistics--2014 update: a report from the American Heart Association. Circulation. 2014;129(3):e28–e292.  https://doi.org/10.1161/01.cir.0000441139.02102.80.CrossRefPubMedGoogle Scholar
  3. 3.
    Keenan NL, Shaw KM. Centers for disease C, prevention. Coronary heart disease and stroke deaths - United States, 2006. MMWR Suppl. 2011;60(1):62–6.PubMedGoogle Scholar
  4. 4.
    Lloyd-Jones DM, Hong Y, Labarthe D, Mozaffarian D, Appel LJ, Van Horn L, et al. Defining and setting national goals for cardiovascular health promotion and disease reduction: the American Heart Association’s strategic Impact Goal through 2020 and beyond. Circulation. 2010;121(4):586–613.  https://doi.org/10.1161/CIRCULATIONAHA.109.192703.CrossRefPubMedGoogle Scholar
  5. 5.
    Yano Y, Reis JP, Tedla YG, Goff DC Jr, Jacobs DR Jr, Sidney S, et al. Racial differences in associations of blood pressure components in young adulthood with incident cardiovascular disease by middle age: Coronary Artery Risk Development in Young Adults (CARDIA) study. JAMA Cardiol. 2017;2(4):381–9.  https://doi.org/10.1001/jamacardio.2016.5678.CrossRefPubMedPubMedCentralGoogle Scholar
  6. 6.
    Mensah GA, Mokdad AH, Ford ES, Greenlund KJ, Croft JB. State of disparities in cardiovascular health in the United States. Circulation. 2005;111(10):1233–41.  https://doi.org/10.1161/01.CIR.0000158136.76824.04.CrossRefPubMedGoogle Scholar
  7. 7.
    Brook RD, Julius S. Autonomic imbalance, hypertension, and cardiovascular risk. Am J Hypertens. 2000;13(6 Pt 2):112S–22S.CrossRefGoogle Scholar
  8. 8.
    Amerena J, Julius S. The role of the autonomic nervous system in hypertension. Hypertens Res. 1995;18(2):99–110.CrossRefGoogle Scholar
  9. 9.
    Julius S, Krause L, Schork NJ, Mejia AD, Jones KA, van de Ven C, et al. Hyperkinetic borderline hypertension in Tecumseh, Michigan. J Hypertens. 1991;9(1):77–84.CrossRefGoogle Scholar
  10. 10.
    Patel PD, Velazquez JL, Arora RR. Endothelial dysfunction in African-Americans. Int J Cardiol. 2009;132(2):157–72.  https://doi.org/10.1016/j.ijcard.2008.10.007.CrossRefPubMedGoogle Scholar
  11. 11.
    Fernandez C, Sander GE, Giles TD. Prehypertension: defining the transitional phenotype. Curr Hypertens Rep. 2016;18(1):2.  https://doi.org/10.1007/s11906-015-0611-8.CrossRefPubMedGoogle Scholar
  12. 12.
    Oparil S, Zaman MA, Calhoun DA. Pathogenesis of hypertension. Ann Intern Med. 2003;139(9):761–76.CrossRefGoogle Scholar
  13. 13.
    Hill LK, Sherwood A, Blumenthal JA, Hinderliter AL. Hemodynamics and vascular hypertrophy in African Americans and Caucasians with high blood pressure. Am J Hypertens. 2016;29(12):1380–5.  https://doi.org/10.1093/ajh/hpw080.CrossRefPubMedPubMedCentralGoogle Scholar
  14. 14.
    Taherzadeh Z, Brewster LM, van Montfrans GA, VanBavel E. Function and structure of resistance vessels in black and white people. J Clin Hypertens (Greenwich). 2010;12(6):431–8.  https://doi.org/10.1111/j.1751-7176.2010.00269.x.CrossRefGoogle Scholar
  15. 15.
    Alpert BS, Barnard M. Prevention of essential hypertension in minority populations. Prog Pediatr Cardiol. 2001;12(2):189–93.CrossRefGoogle Scholar
  16. 16.
    Sherwood A, Hughes JW, McFetridge J. Ethnic differences in the hemodynamic mechanisms of ambulatory blood pressure regulation. Am J Hypertens. 2003;16(4):270–3.  https://doi.org/10.1016/S0895-7061(02)03269-7.CrossRefPubMedGoogle Scholar
  17. 17.
    Sherwood A, Hill LK, Blumenthal JA, Hinderliter AL. Circadian hemodynamics in men and women with high blood pressure: dipper vs. nondipper and racial differences. J Hypertens. 2018;36(2):250–8.  https://doi.org/10.1097/Hjh.0000000000001533.CrossRefPubMedPubMedCentralGoogle Scholar
  18. 18.
    Thomas KS, Nelesen RA, Malcarne VL, Ziegler MG, Dimsdale JE. Ethnicity, perceived discrimination, and vascular reactivity to phenylephrine. Psychosom Med. 2006;68(5):692–7.  https://doi.org/10.1097/01.psy.0000238214.80871.e6.CrossRefPubMedGoogle Scholar
  19. 19.
    Hill LK, Sherwood A, McNeilly M, Anderson NB, Blumenthal JA, Hinderliter AL. Impact of racial discrimination and hostility on adrenergic receptor responsiveness in African American adults. Psychosom Med. 2018;80(2):208–15.  https://doi.org/10.1097/PSY.0000000000000547.CrossRefPubMedPubMedCentralGoogle Scholar
  20. 20.
    Thayer JF, Yamamoto SS, Brosschot JF. The relationship of autonomic imbalance, heart rate variability and cardiovascular disease risk factors. Int J Cardiol. 2010;141(2):122–31.  https://doi.org/10.1016/j.ijcard.2009.09.543.CrossRefPubMedGoogle Scholar
  21. 21.
    Schuster AK, Fischer JE, Thayer JF, Mauss D, Jarczok MN. Decreased heart rate variability correlates to increased cardiovascular risk. Int J Cardiol. 2016;203:728–30.  https://doi.org/10.1016/j.ijcard.2015.11.027.CrossRefPubMedGoogle Scholar
  22. 22.
    Schroeder EB, Liao D, Chambless LE, Prineas RJ, Evans GW, Heiss G. Hypertension, blood pressure, and heart rate variability: the Atherosclerosis Risk in Communities (ARIC) study. Hypertension. 2003;42(6):1106–11.  https://doi.org/10.1161/01.HYP.0000100444.71069.73.CrossRefPubMedGoogle Scholar
  23. 23.
    Alter P, Grimm W, Vollrath A, Czerny F, Maisch B. Heart rate variability in patients with cardiac hypertrophy--relation to left ventricular mass and etiology. Am Heart J. 2006;151(4):829–36.  https://doi.org/10.1016/j.ahj.2005.06.016.CrossRefPubMedGoogle Scholar
  24. 24.
    Kilit C, Pasali Kilit T, Onrat E. Autonomic modulation in hypertension without hypertrophy. Acta Cardiol. 2015;70(6):721–7.  https://doi.org/10.2143/AC.70.6.3120186.CrossRefPubMedGoogle Scholar
  25. 25.
    Kohara K, Hara-Nakamura N, Hiwada K. Left ventricular mass index negatively correlates with heart rate variability in essential hypertension. Am J Hypertens. 1995;8(2):183–8.  https://doi.org/10.1016/0895-7061(94)00190-M.CrossRefPubMedGoogle Scholar
  26. 26.
    Melillo P, Izzo R, De Luca N, Pecchia L. Heart rate variability and target organ damage in hypertensive patients. BMC Cardiovasc Disord. 2012;12:105.  https://doi.org/10.1186/1471-2261-12-105.CrossRefPubMedPubMedCentralGoogle Scholar
  27. 27.
    Burchfiel CM, Skelton TN, Andrew ME, Garrison RJ, Arnett DK, Jones DW, et al. Metabolic syndrome and echocardiographic left ventricular mass in blacks: the Atherosclerosis Risk in Communities (ARIC) study. Circulation. 2005;112(6):819–27.  https://doi.org/10.1161/CIRCULATIONAHA.104.518498.CrossRefPubMedGoogle Scholar
  28. 28.
    Drazner MH, Dries DL, Peshock RM, Cooper RS, Klassen C, Kazi F, et al. Left ventricular hypertrophy is more prevalent in blacks than whites in the general population: the Dallas Heart Study. Hypertension. 2005;46(1):124–9.  https://doi.org/10.1161/01.HYP.0000169972.96201.8e.CrossRefPubMedGoogle Scholar
  29. 29.
    Hanevold C, Waller J, Daniels S, Portman R, Sorof J, International Pediatric Hypertension A. The effects of obesity, gender, and ethnic group on left ventricular hypertrophy and geometry in hypertensive children: a collaborative study of the International Pediatric Hypertension Association. Pediatrics. 2004;113(2):328–33.CrossRefGoogle Scholar
  30. 30.
    Lai CC, Sun D, Cen R, Wang J, Li S, Fernandez-Alonso C, et al. Impact of long-term burden of excessive adiposity and elevated blood pressure from childhood on adulthood left ventricular remodeling patterns: the Bogalusa Heart Study. J Am Coll Cardiol. 2014;64(15):1580–7.  https://doi.org/10.1016/j.jacc.2014.05.072.CrossRefPubMedPubMedCentralGoogle Scholar
  31. 31.
    Lampert R, Ickovics J, Horwitz R, Lee F. Depressed autonomic nervous system function in African Americans and individuals of lower social class: a potential mechanism of race- and class-related disparities in health outcomes. Am Heart J. 2005;150(1):153–60.  https://doi.org/10.1016/j.ahj.2004.08.008.CrossRefPubMedGoogle Scholar
  32. 32.
    Dorr N, Brosschot JF, Sollers JJ, Thayer JF. Damned if you do, damned if you don’t: the differential effect of expression and inhibition of anger on cardiovascular recovery in Black and White males. Int J Psychophysiol. 2007;66(2):125–34.  https://doi.org/10.1016/j.ijpsycho.2007.03.022.CrossRefPubMedGoogle Scholar
  33. 33.
    • Hill LK, Hu DD, Koenig J, Sollers JJ 3rd, Kapuku G, Wang X, et al. Ethnic differences in resting heart rate variability: a systematic review and meta-analysis. Psychosom Med. 2015;77(1):16–25.  https://doi.org/10.1097/PSY.0000000000000133 This meta-analysis reviews and quantifies the existing literature on ethnic (i.e., Black-White) differences in resting vagally mediated heart rate variability (HRV). Results of the meta-analysis indicate that African Americans tend to exhibit higher HRV relative to European Americans. CrossRefPubMedPubMedCentralGoogle Scholar
  34. 34.
    Hill LK, Hoggard LS, Richmond AS, Gray DL, Williams DP, Thayer JF. Examining the association between perceived discrimination and heart rate variability in African Americans. Cultur Divers Ethnic Minor Psychol. 2017;23(1):5–14.  https://doi.org/10.1037/cdp0000076.CrossRefPubMedPubMedCentralGoogle Scholar
  35. 35.
    Liao DP, Barnes RW, Chambless LE, Simpson RJ, Sorlie P, Heiss G. Age, race, and sex-differences in autonomic cardiac-function measured by spectral-analysis of heart-rate-variability - the Aric study. Am J Cardiol. 1995;76(12):906–12.  https://doi.org/10.1016/S0002-9149(99)80260-4.CrossRefPubMedGoogle Scholar
  36. 36.
    Urbina EM, Bao WH, Pickoff AS, Berenson GS. Ethnic (black-white) contrasts in heart rate variability during cardiovascular reactivity testing in male adolescents with high and low blood pressure - the Bogalusa Heart Study. Am J Hypertens. 1998;11(2):196–202.  https://doi.org/10.1016/S0895-7061(97)00314-2.CrossRefPubMedGoogle Scholar
  37. 37.
    Ohira T, Roux AVD, Prineas RJ, Kizilbash MA, Carnethon MR, Folsom AR. Associations of psychosocial factors with heart rate and its short-term variability: multi-ethnic study of atherosclerosis. Psychosom Med. 2008;70(2):141–6.  https://doi.org/10.1097/PSY.0b013e318160686a.CrossRefPubMedGoogle Scholar
  38. 38.
    Zion AS, Bond V, Adams RG, Williams D, Fullilove RE, Sloan RP, et al. Low arterial compliance in young African-American males. Am J Physiol Heart Circ Physiol. 2003;285(2):H457–62.  https://doi.org/10.1152/ajpheart.00497.2002.CrossRefPubMedGoogle Scholar
  39. 39.
    Choi JB, Hong S, Nelesen R, Bardwell WA, Natarajan L, Schubert C, et al. Age and ethnicity differences in short-term heart-rate variability. Psychosom Med. 2006;68(3):421–6.  https://doi.org/10.1097/01.psy.0000221378.09239.6a.CrossRefPubMedGoogle Scholar
  40. 40.
    Arthur CM, Katkin ES, Mezzacappa ES. Cardiovascular reactivity to mental arithmetic and cold pressor in African Americans, Caribbean Americans, and white Americans. Ann Behav Med. 2004;27(1):31–7.  https://doi.org/10.1207/s15324796abm2701_5.CrossRefPubMedGoogle Scholar
  41. 41.
    Franke WD, Lee K, Buchanan DB, Hernandez JP. Blacks and whites differ in responses, but not tolerance, to orthostatic stress. Clin Auton Res. 2004;14(1):19–25.  https://doi.org/10.1007/s10286-004-0155-5.CrossRefPubMedGoogle Scholar
  42. 42.
    Stein PK, Freedland KE, Skala JA, Carney RM, DavilaRoman V, Rich MW, et al. Heart rate variability is independent of age, gender, and race in congestive heart failure with a recent acute exacerbation. Am J Cardiol. 1997;79(4):511-&.  https://doi.org/10.1016/S0002-9149(96)00798-9.CrossRefPubMedGoogle Scholar
  43. 43.
    • Kemp AH, Koenig J, Thayer JF, Bittencourt MS, Pereira AC, Santos IS, et al. Race and resting-state heart rate variability in Brazilian civil servants and the mediating effects of discrimination: an ELSA-Brasil Cohort Study. Psychosom Med. 2016;78(8):950–8.  https://doi.org/10.1097/PSY.0000000000000359 This study examines differences in resting vagally mediated heart rate variability in a large Brazilian cohort. Significant differences are revealed such that Brazilians self-identifying as either Black or Brown exhibit higher resting HRV relative to individuals identifying as White. In addition, racial discrimination was shown to indirectly contribute to group differences in HRV. CrossRefPubMedGoogle Scholar
  44. 44.
    Boylan JM, Jennings JR, Matthews KA. Childhood socioeconomic status and cardiovascular reactivity and recovery among Black and White men: mitigating effects of psychological resources. Health Psychol. 2016;35(9):957–66.  https://doi.org/10.1037/hea0000355.CrossRefPubMedPubMedCentralGoogle Scholar
  45. 45.
    Fuller-Rowell TE, Williams DR, Love GD, McKinley PS, Sloan RP, Ryff CD. Race differences in age-trends of autonomic nervous system functioning. J Aging Health. 2013;25(5):839–62.  https://doi.org/10.1177/0898264313491427.CrossRefPubMedPubMedCentralGoogle Scholar
  46. 46.
    Sloan RP, Huang MH, Sidney S, Liu K, Williams OD, Seeman T. Socioeconomic status and health: is parasympathetic nervous system activity an intervening mechanism? Int J Epidemiol. 2005;34(2):309–15.  https://doi.org/10.1093/ije/dyh381.CrossRefPubMedPubMedCentralGoogle Scholar
  47. 47.
    Hill LK, Hoggard LS. Cultural influences on parasympathetic activity. In: The Handbook of Culture and Biology; 2017.  https://doi.org/10.1002/9781119181361.ch14.CrossRefGoogle Scholar
  48. 48.
    Steptoe A, Feldman RJ, Kunz S, Owen N, Willemsen G, Marmot M. Stress responsivity and socioeconomic status - a mechanism for increased cardiovascular disease risk? Eur Heart J. 2002;23(22):1757–63.  https://doi.org/10.1053/euhj.2001.3233.CrossRefPubMedGoogle Scholar
  49. 49.
    Steptoe A, Marmot M. The role of psychobiological pathways in socio-economic inequalities in cardiovascular disease risk. Eur Heart J. 2002;23(1):13–25.  https://doi.org/10.1053/euhj.2001.2611.CrossRefPubMedGoogle Scholar
  50. 50.
    Palatini P, Julius S. The role of cardiac autonomic function in hypertension and cardiovascular disease. Curr Hypertens Rep. 2009;11(3):199–205.  https://doi.org/10.1007/s11906-009-0035-4.CrossRefPubMedGoogle Scholar
  51. 51.
    Anderson NB, McNeilly M, Myers H. Toward understanding race difference in autonomic reactivity. Individual differences in cardiovascular response to stress. Berlin: Springer; 1992. p. 125–45.CrossRefGoogle Scholar
  52. 52.
    Clark R, Anderson NB, Clark VR, Williams DR. Racism as a stressor for African Americans - a biopsychosocial model. Am Psychol. 1999;54(10):805–16.  https://doi.org/10.1037//0003-066x.54.10.805.CrossRefPubMedGoogle Scholar
  53. 53.
    Brosschot JF, Thayer JF. Anger inhibition, cardiovascular recovery, and vagal function: a model of the link between hostility and cardiovascular disease. Ann Behav Med. 1998;20(4):326–32.  https://doi.org/10.1007/BF02886382.CrossRefPubMedGoogle Scholar
  54. 54.
    Wong MD, Shapiro MF, Boscardin WJ, Ettner SL. Contribution of major diseases to disparities in mortality. N Engl J Med. 2002;347(20):1585–92.  https://doi.org/10.1056/NEJMsa012979.CrossRefPubMedGoogle Scholar
  55. 55.
    Chae DH, Clouston S, Hatzenbuehler ML, Kramer MR, Cooper HL, Wilson SM, et al. Association between an internet-based measure of area racism and black mortality. PLoS One. 2015;10(4):e0122963.  https://doi.org/10.1371/journal.pone.0122963.CrossRefPubMedPubMedCentralGoogle Scholar
  56. 56.
    Greer S, Kramer MR, Cook-Smith JN, Casper ML. Metropolitan racial residential segregation and cardiovascular mortality: exploring pathways. J Urban Health. 2014;91(3):499–509.  https://doi.org/10.1007/s11524-013-9834-7.CrossRefPubMedGoogle Scholar
  57. 57.
    Din-Dzietham R, Nembhard WN, Collins R, Davis SK. Perceived stress following race-based discrimination at work is associated with hypertension in African-Americans. The metro Atlanta heart disease study, 1999-2001. Soc Sci Med. 2004;58(3):449–61.CrossRefGoogle Scholar
  58. 58.
    Sims M, Diez-Roux AV, Dudley A, Gebreab S, Wyatt SB, Bruce MA, et al. Perceived discrimination and hypertension among African Americans in the Jackson Heart study. Am J Public Health. 2012;102(Suppl 2):S258–65.  https://doi.org/10.2105/AJPH.2011.300523.CrossRefPubMedPubMedCentralGoogle Scholar
  59. 59.
    Troxel WM, Matthews KA, Bromberger JT, Sutton-Tyrrell K. Chronic stress burden, discrimination, and subclinical carotid artery disease in African American and Caucasian women. Health Psychol. 2003;22(3):300–9.CrossRefGoogle Scholar
  60. 60.
    Cooper DC, Mills PJ, Bardwell WA, Ziegler MG, Dimsdale JE. The effects of ethnic discrimination and socioeconomic status on endothelin-1 among blacks and whites. Am J Hypertens. 2009;22(7):698–704.  https://doi.org/10.1038/ajh.2009.72.CrossRefPubMedPubMedCentralGoogle Scholar
  61. 61.
    Beatty DL, Matthews KA, Bromberger JT, Brown C. Everyday discrimination prospectively predicts inflammation across 7-years in racially diverse midlife women: study of women’s health across the nation. J Soc Issues. 2014;70(2):298–314.  https://doi.org/10.1111/josi.12061.CrossRefPubMedPubMedCentralGoogle Scholar
  62. 62.
    Lewis TT, Aiello AE, Leurgans S, Kelly J, Barnes LL. Self-reported experiences of everyday discrimination are associated with elevated C-reactive protein levels in older African-American adults. Brain Behav Immun. 2010;24(3):438–43.  https://doi.org/10.1016/j.bbi.2009.11.011.CrossRefPubMedGoogle Scholar
  63. 63.
    Neblett EW, Roberts SO. Racial identity and autonomic responses to racial discrimination. Psychophysiology. 2013;50(10):943–53.  https://doi.org/10.1111/psyp.12087.CrossRefPubMedGoogle Scholar
  64. 64.
    Wagner J, Lampert R, Tennen H, Feinn R. Exposure to discrimination and heart rate variability reactivity to acute stress among women with diabetes. Stress Health. 2015;31(3):255–62.  https://doi.org/10.1002/smi.2542.CrossRefPubMedGoogle Scholar
  65. 65.
    Hoggard LS, Hill LK, Gray DL, Sellers RM. Capturing the cardiac effects of racial discrimination: do the effects “keep going”? Int J Psychophysiol. 2015;97(2):163–70.  https://doi.org/10.1016/j.ijpsycho.2015.04.015.CrossRefPubMedPubMedCentralGoogle Scholar
  66. 66.
    Williams DP, Joseph N, Hill LK, Sollers JJ 3rd, Vasey MW, Way BM, et al. Stereotype threat, trait perseveration, and vagal activity: evidence for mechanisms underpinning health disparities in Black Americans. Ethn Health. 2017:1–18.  https://doi.org/10.1080/13557858.2017.1378803.
  67. 67.
    Williams DP, Pandya KD, Hill LK, Kemp AH, Way BM, Thayer JF, et al. Rumination moderates the association between resting high-frequency heart rate variability and perceived ethnic discrimination. J Psychophysiol. 2017:No Pagination Specified-No Pagination Specified.  https://doi.org/10.1027/0269-8803/a000201.
  68. 68.
    Borders A, Liang CTH. Rumination partially mediates the associations between perceived ethnic discrimination, emotional distress, and aggression. Cult Divers Ethn Min. 2011;17(2):125–33.CrossRefGoogle Scholar
  69. 69.
    Hatzenbuehler ML, Nolen-Hoeksema S, Dovidio J. How does stigma “get under the skin”?: the mediating role of emotion regulation. Psychol Sci. 2009;20(10):1282–9.  https://doi.org/10.1111/j.1467-9280.2009.02441.x.CrossRefPubMedPubMedCentralGoogle Scholar
  70. 70.
    Miranda R, Polanco-Roman L, Tsypes A, Valderrama J. Perceived discrimination, ruminative subtypes, and risk for depressive symptoms in emerging adulthood. Cultur Divers Ethnic Minor Psychol. 2013;19(4):395–403.  https://doi.org/10.1037/a0033504.CrossRefPubMedPubMedCentralGoogle Scholar
  71. 71.
    Ottaviani C, Thayer JF, Verkuil B, Lonigro A, Medea B, Couyoumdjian A, et al. Physiological concomitants of perseverative cognition: a systematic review and meta-analysis. Psychol Bull. 2016;142(3):231–59.  https://doi.org/10.1037/bul0000036.CrossRefPubMedGoogle Scholar
  72. 72.
    Wang X, Thayer JF, Treiber F, Snieder H. Ethnic differences and heritability of heart rate variability in African- and European American youth. Am J Cardiol. 2005;96(8):1166–72.  https://doi.org/10.1016/j.amjcard.2005.06.050.CrossRefPubMedGoogle Scholar
  73. 73.
    Kemp AH, Quintana DS. The relationship between mental and physical health: insights from the study of heart rate variability. Int J Psychophysiol. 2013;89(3):288–96.  https://doi.org/10.1016/j.ijpsycho.2013.06.018.CrossRefPubMedGoogle Scholar
  74. 74.
    Keen L 2nd, Turner AD, Mwendwa D, Callender C, Campbell A Jr. Depressive symptomatology and respiratory sinus arrhythmia in a non-clinical sample of middle-aged African Americans. Biol Psychol. 2015;108:56–61.  https://doi.org/10.1016/j.biopsycho.2015.03.008.CrossRefPubMedPubMedCentralGoogle Scholar
  75. 75.
    Hill LK, Watkins LL, Hinderliter AL, Blumenthal JA, Sherwood A. Racial differences in the association between heart rate variability and left ventricular mass. Exp Physiol. 2017;102(7):764–72.  https://doi.org/10.1113/EP086228.CrossRefPubMedPubMedCentralGoogle Scholar
  76. 76.
    Yoo HJ, Thayer JF, Greening S, Lee TH, Ponzio A, Min J, et al. Brain structural concomitants of resting state heart rate variability in the young and old: evidence from two independent samples. Brain Struct Funct. 2018;223(2):727–37.  https://doi.org/10.1007/s00429-017-1519-7.CrossRefPubMedGoogle Scholar
  77. 77.
    Holzman JB, Bridgett DJ. Heart rate variability indices as bio-markers of top-down self-regulatory mechanisms: a meta-analytic review. Neurosci Biobehav Rev. 2017;74(Pt A):233–55.  https://doi.org/10.1016/j.neubiorev.2016.12.032.CrossRefPubMedGoogle Scholar
  78. 78.
    Zahn D, Adams J, Krohn J, Wenzel M, Mann CG, Gomille LK, et al. Heart rate variability and self-control--a meta-analysis. Biol Psychol. 2016;115:9–26.  https://doi.org/10.1016/j.biopsycho.2015.12.007.CrossRefPubMedGoogle Scholar
  79. 79.
    Lohmeier TE, Irwin ED, Rossing MA, Serdar DJ, Kieval RS. Prolonged activation of the baroreflex produces sustained hypotension. Hypertension. 2004;43(2):306–11.  https://doi.org/10.1161/01.HYP.0000111837.73693.9b.CrossRefPubMedGoogle Scholar
  80. 80.
    Lohmeier TE. The sympathetic nervous system and long-term blood pressure regulation. Am J Hypertens. 2001;14(6 Pt 2):147S–54S.CrossRefGoogle Scholar
  81. 81.
    Hesse C, Charkoudian N, Liu Z, Joyner MJ, Eisenach JH. Baroreflex sensitivity inversely correlates with ambulatory blood pressure in healthy normotensive humans. Hypertension. 2007;50:41–6.  https://doi.org/10.1161/hypertensionaha.107.090308.CrossRefPubMedGoogle Scholar
  82. 82.
    Benarroch EE. The arterial baroreflex functional organization and involvement in neurologic disease. Neurology. 2008;71(21):1733–8.  https://doi.org/10.1212/01.wnl.0000335246.93495.92.CrossRefPubMedGoogle Scholar
  83. 83.
    Duschek S, del Paso GAR. Quantification of cardiac baroreflex function at rest and during autonomic. J Physiol Sci. 2007;57(5):259–68.  https://doi.org/10.2170/physiolsci.RP008807.
  84. 84.
    Liao D, Cai J, Barnes RW, Tyroler HA, Rautaharju P, Holme I, et al. Association of cardiac autonomic function and the development of hypertension: the ARIC study. Am J Hypertens. 1996;9(12 Pt 1):1147–56.CrossRefGoogle Scholar
  85. 85.
    Palatini P, Longo D, Zaetta V, Perkovic D, Garbelotto R, Pessina AC. Evolution of blood pressure and cholesterol in stage 1 hypertension: role of autonomic nervous system activity. J Hypertens. 2006;24(7):1375–81.  https://doi.org/10.1097/01.hjh.0000234118.25401.1c.CrossRefPubMedGoogle Scholar
  86. 86.
    Propper C, Moore GA, Mills-Koonce WR, Halpern CT, Hill-Soderlund AL, Calkins SD, et al. Gene-environment contributions to the development of infant vagal reactivity: the interaction of dopamine and maternal sensitivity. Child Dev. 2008;79(5):1377–94.  https://doi.org/10.1111/j.1467-8624.2008.01194.x.CrossRefPubMedGoogle Scholar

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© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Psychiatry and Behavioral SciencesDuke University Medical CenterDurhamUSA
  2. 2.Center for Biobehavioral Health Disparities ResearchDuke UniversityDurhamUSA
  3. 3.Department of PsychologyThe Ohio State UniversityColumbusUSA

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