Quantification of PET Myocardial Blood Flow

  • Matthieu Pelletier-Galarneau
  • Patrick Martineau
  • Georges El FakhriEmail author
Nuclear Cardiology (V Dilsizian, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Nuclear Cardiology


Purpose of Review

The aim of this review is to provide an update on quantification of myocardial blood flow (MBF) with positron emission tomography (PET) imaging. Technical and clinical aspects of flow quantification with PET are reviewed.

Recent Findings

The diagnostic and prognostic values of myocardial flow quantification have been established in numerous studies and in various populations. MBF quantification has also shown itself to be particularly useful in the assessment of coronary microvascular dysfunction and in evaluation of cardiac allograft vasculopathy. Overall, myocardial flow reserve (MFR) and hyperemic MBF can lead to improved risk stratification by providing information complementary to that of other markers of disease severity, such as fractional flow reserve.


Flow quantification enhances MPI’s ability to detect both significant epicardial disease and microvascular dysfunction. With recent technological and methodological advances, flow quantification with PET is no longer restricted to cyclotron-equipped academic centers.


Positron emission tomography Myocardial blood flow Myocardial flow reserve Coronary artery disease Myocardial perfusion imaging 


Compliance with Ethical Standards

Conflict of Interest

Matthieu Pelletier-Galarneau and Patrick Martineau declare that they have no conflict of interest.

Georges El Fakhri reports a patent issued that is titled Fast, Unique and Robust Factor Analysis (on estimation of Inout Function and Quantification of MBF) with royalties paid to INVIA, LLC.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Matthieu Pelletier-Galarneau
    • 1
    • 2
  • Patrick Martineau
    • 1
    • 3
  • Georges El Fakhri
    • 1
    Email author
  1. 1.Gordon Center for Medical ImagingMassachusetts General Hospital and Harvard Medical SchoolBostonUSA
  2. 2.Department of Medical ImagingMontreal Heart InstituteMontrealCanada
  3. 3.Department of Radiology, Health Sciences CentreUniversity of ManitobaWinnipegCanada

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