Transcatheter Pulmonary Valve Replacement: Current State of Art

  • Wail AlkashkariEmail author
  • Amani Alsubei
  • Ziyad M. Hijazi
Structural Heart Disease (RJ Siegel and NC Wunderlich, Section Editors)
Part of the following topical collections:
  1. Topical Collection on Structural Heart Disease


Purpose of Review

The past couple of decades have brought tremendous advances to the field of pediatric and adult congenital heart disease (CHD). Percutaneous valve interventions are now a cornerstone of not just the congenital cardiologist treating patients with congenital heart disease, but also—and numerically more importantly—for adult interventional cardiologists treating patients with acquired heart valve disease. Transcatheter pulmonary valve replacement (tPVR) is one of the most exciting recent developments in the treatment of CHD and has evolved to become an attractive alternative to surgery in patients with right ventricular outflow tract (RVOT) dysfunction. This review aims to summarize (1) the current state of the art for tPVR, (2) the expanding indications, and (3) the technological obstacles to optimizing tPVR.

Recent Findings

Since its introduction in 2000, more than ten thousands tPVR procedures have been performed worldwide. Although the indications for tPVR have been adapted earlier from those accepted for surgical intervention, they remain incompletely defined. The new imaging modalities give better assessment of cardiac anatomy and function and determine candidacy for the procedure. The procedure has been shown to be feasible and safe when performed in patients who received pulmonary conduit and or bioprosthetic valves between the right ventricle and the pulmonary artery. Fewer selected patients post trans-annular patch repair for tetralogy of Fallot may also be candidates for this technology. Size restrictions of the currently available valves limit deployment in the majority of patients post trans-annular patch repair. Newer valves and techniques are being developed that may help such patients.


Refinements and further developments of this procedure hold promise for the extension of this technology to other patient populations.


Congenital heart disease Tetralogy of Fallot Pulmonary stenosis Pulmonary regurgitation Right ventricular outflow tract dysfunction Transcatheter pulmonary valve replacement 


Compliance with Ethical Standards

Conflict of Interest

Wail Alkashkari and Amani Alsubei declare that they have no conflict of interest.

Ziyad M. Hijazi is a consultant for Venus Medtech.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

Supplementary material

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Papers of particular interest, published recently, have been highlighted as: • Of importance, •• Of major importance

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Wail Alkashkari
    • 1
    Email author
  • Amani Alsubei
    • 1
  • Ziyad M. Hijazi
    • 2
    • 3
  1. 1.King Saud Bin Abdulaziz University For Health Science & King Faisal Cardiac Center, King Abdulaziz Medical City for National GuardJeddahSaudi Arabia
  2. 2.Sidra Cardiac Program, Sidra Medical & Research CenterDohaQatar
  3. 3.Weill Cornell MedicineNew YorkUSA

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