Does Supplementation with Omega-3 PUFAs Add to the Prevention of Cardiovascular Disease?

  • Evangelos C. Rizos
  • Moses S. ElisafEmail author
Lipid Abnormalities and Cardiovascular Prevention (G De Backer, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Lipid Abnormalities and Cardiovascular Prevention


Purpose of Review

Omega-3 fatty acids are increasingly used for the protection of cardiovascular disease. The main but not the sole mechanism of action is the reduction of triglyceride levels. In this review, we summarize the effect of omega-3 supplements on all-cause and cardiovascular mortality, myocardial infarction, and stroke from the relevant randomized controlled trials.

Recent Findings

Twenty-one randomized controlled trials assessed omega-3 supplementation on mortality and cardiovascular-related outcomes. From these studies, as well as from the relevant meta-analyses, we found that omega-3 supplements do not exert a consistent benefit for cardiovascular protection.


There is uncertainty of a clear profit from omega-3 supplementation in cardiovascular disease.


Omega 3 Polyunsaturated fatty acids Fish oil Cardiovascular Myocardial infarction Death 


Compliance with Ethical Standards

Conflict of Interest

Both authors comply with ethical standards and are in line with best practices and codes of conduct of relevant professional bodies and/or national and international regulatory bodies. This study was not funded. The authors have received no payment in preparation of this manuscript. Evangelos C. Rizos and Moses S. Elisaf have given talks, attended conferences, and participated in trials and advisory boards sponsored by various pharmaceutical companies (Novartis, Sanofi, NovoNordisk, Pfizer, AstraZeneca/BMS, Eli Lilly, MSD/Vianex, Boehringer Ing, Amgen, GSK, Plus Pharmaceuticals, WinMedica, Elpen etc.).

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance

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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  1. 1.Department of Internal MedicineUniversity Hospital of IoanninaIoanninaGreece
  2. 2.University of Cyprus Medical SchoolNicosiaCyprus
  3. 3.University of Ioannina Medical SchoolIoanninaGreece

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