Nonatherosclerotic PAD: Approach to Exertional Pain in the Lower Extremities

  • Ari J. Mintz
  • Ido WeinbergEmail author
Peripheral Vascular Disease (MR Jaff, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Peripheral Vascular Disease


Atherosclerotic peripheral artery disease is the most common cause of intermittent claudication. Nonatherosclerotic peripheral artery disease is a heterogeneous collection of diseases affecting the extracoronary arteries which is not due to atherosclerosis. These diseases include, but are not limited to, popliteal artery entrapment syndrome, cystic adventitial disease, external iliac endofibrosis, and thromboangiitis obliterans. Due to its relatively low prevalence, nonatherosclerotic peripheral artery disease may be misdiagnosed leading to the mismanagement of potentially treatable conditions. The proper and timely diagnosis of these conditions is paramount to the prevention of adverse outcomes as treatments widely vary. The diagnostic approach to patients presenting with intermittent claudication must take into account both atherosclerotic as well as nonatherosclerotic causes of peripheral artery disease making the differential vital to clinical practice.


Peripheral artery disease Intermittent claudication Nonatherosclerotic peripheral artery disease 


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Conflict of Interest

Ari J. Mintz and Ido Weinberg declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


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© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Internal MedicineLahey Hospital and Medical CenterBurlingtonUSA
  2. 2.Vascular MedicineMassachusetts General HospitalBostonUSA

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