Current Cardiology Reports

, 16:465

Assessing Clinical Impact of Myocardial Perfusion Studies: Ischemia or Other Prognostic Indicators?

  • Todd D. Miller
  • John Wells Askew
  • Joerg Herrmann
Nuclear Cardiology (V Dilsizian, Section Editor)

DOI: 10.1007/s11886-014-0465-8

Cite this article as:
Miller, T.D., Askew, J.W. & Herrmann, J. Curr Cardiol Rep (2014) 16: 465. doi:10.1007/s11886-014-0465-8
Part of the following topical collections:
  1. Topical Collection on Nuclear Cardiology


One of the major strengths of nuclear myocardial perfusion imaging (MPI) is the robust prognostic databases from observational studies demonstrating significantly different outcomes in patients with low-risk vs high-risk scans. The severity of the MPI defect can be semi-quantitated using the summed stress score (SSS) and summed difference score (SDS). SSS is more strongly associated with mortality, whereas SDS is the better predictor of subsequent coronary angiography and revascularization. The strength of MPI variables as prognostic indicators decreases when adjusted for prognostically important clinical and stress test variables. Nonetheless, most studies of general patient populations have demonstrated that MPI adds incremental prognostic value to clinical and stress test information. In contrast to these positive results from observational studies, the application of MPI ischemia as a treatment guide in several recent trials (DIAD, WOMEN, COURAGE, BARI 2D, STICH) has largely failed to identify patient subsets with improved outcome. This issue will continue to be investigated in the ongoing PROMISE and ISCHEMIA trials.


SPECT (single photon emission computed tomography) MPI (myocardial perfusion imaging) Summed stress score Summed difference score Ischemia Prognosis Coronary artery disease 

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Todd D. Miller
    • 1
    • 2
  • John Wells Askew
    • 1
  • Joerg Herrmann
    • 1
  1. 1.Division of Cardiovascular Diseases and the Department of Internal MedicineMayo ClinicRochesterUSA
  2. 2.Mayo ClinicRochesterUSA

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