Current State of Anticoagulants to Treat Deep Venous Thrombosis

  • Timothy Vo
  • Sara Vazquez
  • Matthew T. RondinaEmail author
Peripheral Vascular Disease (MH Shishehbor, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Peripheral Vascular Disease


Anticoagulation remains the cornerstone of treatment in patients with deep vein thrombosis (DVT). While parenteral anticoagulants and oral vitamin K antagonists (e.g., warfarin) have been used for many decades, the recent development of novel oral anticoagulants have provided clinicians with an expanding set of therapeutic options for DVT. This review summarizes the pharmacology and clinical trial results of these new oral anticoagulants. Several practical considerations to the use of these oral anticoagulants including issues related to adherence, monitoring, and reversal are also discussed.


Deep vein thrombosis Anticoagulants Rivaroxaban Dabigatran Apixaban Edoxaban Warfarin 



This work was supported by the National Institutes of Health and the National Institute of Aging (K23HL092161 and R03AG040631 to M.T.R.). We thank Ms. Alex Greer for her excellent editorial assistance.

Compliance with Ethics Guidelines

Conflict of Interest

Timothy Vo declares that he has no conflict of interest.

Sara Vazquez declares that she has no conflict of interest.

Matthew T. Rondina has received honoraria from Boehringer Ingelheim for Advisory Board participation.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Timothy Vo
    • 1
  • Sara Vazquez
    • 2
  • Matthew T. Rondina
    • 3
    • 4
    • 5
    Email author
  1. 1.SUNY Upstate Medical UniversitySyracuseUSA
  2. 2.Department of Pharmacy ServicesUniversity of Utah Health Care Thrombosis CenterSalt Lake CityUSA
  3. 3.Division of General Internal Medicine and University Healthcare Thrombosis Service, Department of Internal MedicineUniversity of Utah Health Sciences CenterSalt Lake CityUSA
  4. 4.Program in Molecular MedicineUniversity of Utah Health Sciences CenterSalt Lake CityUSA
  5. 5.Department of Internal Medicine, Eccles Institute of Human GeneticsUniversity of UtahSalt Lake CityUSA

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