Current Cardiology Reports

, 16:447 | Cite as

The Current State of Stem Cell Therapy for Peripheral Artery Disease

  • Nitin K. Gupta
  • Ehrin J. Armstrong
  • Sahil A. Parikh
Peripheral Vascular Disease (MH Shishehbor, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Peripheral Vascular Disease

Abstract

Patients with advanced peripheral arterial disease may develop critical limb ischemia with rest pain, non-healing ulcerations, and eventually may require major amputation despite currently available revascularization technologies. Stem cell therapies hold promise as novel therapeutics to promote vasculogenesis and improve tissue perfusion in these patients. This article reviews the current state of stem cell therapy for patients with peripheral arterial disease, with a focus on the cell types that have been studied, barriers to clinical development, and development of new endpoints for clinical trials.

Keywords

Stem cells Peripheral artery disease Critical limb ischemia 

Notes

Compliance with Ethics Guidelines

Conflict of Interest

Nitin K. Gupta, Ehrin J. Armstrong, and Sahil A. Parikh declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Nitin K. Gupta
    • 1
    • 2
  • Ehrin J. Armstrong
    • 3
  • Sahil A. Parikh
    • 1
    • 2
    • 4
  1. 1.Division of Cardiovascular Medicine, Harrington Heart & Vascular InstituteUniversity Hospitals Case Medical CenterClevelandUSA
  2. 2.Department of MedicineCase Western Reserve University School of MedicineClevelandUSA
  3. 3.Division of CardiologyUniversity of Colorado School of Medicine and VA Eastern Colorado Healthcare System DenverUSA
  4. 4.Division of Cardiovascular Medicine, Harrington Heart & Vascular InstituteUniversity Hospitals Case Medical CenterClevelandUSA

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