Current Cardiology Reports

, 15:410 | Cite as

Antiarrhythmic Drugs 2013: State of the Art

Invasive Electrophysiology and Pacing (J Singh, Section Editor)
Part of the following topical collections:
  1. Topical Collection on Invasive Electrophysiology and Pacing

Abstract

Antiarrhythmic drugs are widely used, but are of modest efficacy and have important side effects. However, even with the advance of catheter ablation for atrial fibrillation and ventricular tachycardia, antiarrhythmic drugs remain an important tool for treating arrhythmias. Antiarrhythmic drug development has remained slow despite much effort given our limited understanding of what role various ionic currents play in arrhythmogenesis and how they are modified by arrhythmias. This review will focus on promising new antiarrhythmic drugs undergoing clinical investigation or currently approved for clinical use, including amiodarone analogues, agents with novel ionic targets, and new drug combinations.

Keywords

Atrial fibrillation Ventricular tachycardia Antiarrhythmic drugs Amiodarone analogues Dronedarone Celivarone Budiodarone Ranolazine Vernakalant Azimilide Ivabradine Drug synergy 

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Harvard Vanguard Medical AssociatesBostonUSA
  2. 2.Division of CardiologyBeth Israel Deaconess Medical CenterBostonUSA

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