Interventional Treatment of Hypertension: A New Paradigm
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Hypertension is thought to contribute to more than 7 million deaths worldwide each year and contributes to the development of atherosclerotic lesions that lead to myocardial infarction and stroke. While lifestyle modifications (diet, exercise, weight loss) and pharmacotherapy have been proven to be effective in the treatment of hypertension, as many as half of patients have uncontrolled BP and remain at risk for elevated cardiovascular morbidity and mortality. The main physiologic targets for interventional treatment include alteration of blood flow to the kidney, activation of the carotid baroreflex system, and modification of the renal sympathetic nervous system. The results of prior studies and new studies of interventional treatments of resistant hypertension are covered in this review.
KeywordsHypertension Resistant hypertension Baroreceptor activation therapy Renal artery stenosis Renal sympathetic denervation
Duke University is a clinical site involved in enrollment of patients in SYMPLICITY HTN-3. As such, Duke receives research money to participate. All 3 of the authors are site investigators but do not receive salary or other compensation for this project.
Conflict of Interest
W.S. Jones declares that he has no conflict of interest.
S. Vemulapalli has received grant support from Medtronic for a peripheral vascular disease fellowship grant. He has also received travel/accommodations expenses covered or reimbursed from Medtronic for travel costs for SYMPLICITY HTN-3 investigators meeting.
M.R. Patel has been a consultant for Genzyme, Baxter, Jensen, and Bayer. He has received grant support from AstraZeneca, Johnson & Johnson, and Maquet.
Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance
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