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Current Cardiology Reports

, 13:478 | Cite as

Can Catheter-Based Renal Denervation Be Used Safely and Effectively to Substantially Reduce Blood Pressure in Treatment-Resistant Hypertensive Patients?

  • Suzanne OparilEmail author
Clinical Trial Report

Trial: Esler MD, Krum H, Sobotka PA, et al.: Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomised controlled trial. Lancet 2010, 376:1903–1909.

Rating: Of significant importance.

Introduction:Successful treatment of elevated blood pressure (BP) has proven elusive despite availability of various drugs, combination pharmaceutical products, and resources to assist patients’ adherence and lifestyle changes. The failure of present strategies suggests underlying pathophysiology that is refractory to available interventions. Renal sympathetic nerves contribute to development and perpetuation of hypertension, and sympathetic outflow to the kidneys is activated in patients with essential hypertension. Efferent sympathetic outflow stimulates renin release, increases tubular sodium reabsorption, and reduces renal blood flow. Afferent signals from the kidney modulate central sympathetic outflow and thereby directly contribute...

Keywords

Renal denervation Resistant hypertension Sympathectomy Blood pressure 

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, Department of Medicine, School of MedicineUniversity of Alabama at BirminghamBirminghamUSA

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