Current Cardiology Reports

, Volume 12, Issue 5, pp 389–392

Can Ablation Prevent the Excess Mortality of Atrial Fibrillation?

Article

DOI: 10.1007/s11886-010-0123-8

Cite this article as:
Anter, E. & Callans, D.J. Curr Cardiol Rep (2010) 12: 389. doi:10.1007/s11886-010-0123-8

Abstract

The relative merits of rate and rhythm control in the treatment of patients with atrial fibrillation have been compared in several major clinical trials, none of which demonstrated a significant difference in all-cause mortality. Yet, there is clear evidence that restoration and maintenance of sinus rhythm is associated with beneficial reverse atrial remodeling. These apparently contradictory findings may reflect the combination of serious adverse effects coupled with limited efficacy of currently available antiarrhythmic drugs, counterbalancing their beneficial effect in restoring sinus rhythm. Catheter ablation offers an alternative means of restoring sinus rhythm in patients with atrial fibrillation, and several clinical trials have indicated its superior outcomes and improved benefit/risk profile. Ongoing trials will soon determine its overall impact on survival.

Keywords

Atrial fibrillation Antiarrhythmic drug Catheter ablation Sinus rhythm 

Clinical Trial Acronyms

AFFIRM

Atrial Fibrillation Follow-Up Investigation of Rhythm Management

APAF

Ablation for Paroxysmal Atrial Fibrillation

CABANA

Catheter Ablation Versus Antiarrhythmic Drug Therapy for Atrial Fibrillation

CACAF

Catheter Ablation for the Cure of Atrial Fibrillation Study

DIAMOND

Danish Investigations of Arrhythmia and Mortality on Dofetilide

HOT CAFE

How to Treat Chronic Atrial Fibrillation

PIAF

Pharmacological Intervention in Atrial Fibrillation

RAAFT

Radiofrequency Ablation Versus Antiarrhythmic Drugs for Atrial Fibrillation Treatment

RACE

Rate Control Versus Electrical Cardioversion

STAF

Strategies of Treatment of Atrial Fibrillation

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Cardiovascular DivisionHospital of the University of PennsylvaniaPhiladelphiaUSA

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