Current Cardiology Reports

, Volume 12, Issue 4, pp 283–285 | Cite as

PLATO Study of Ticagrelor Versus Clopidogrel in Patients With High-Risk Acute Coronary Syndromes

Clinical Trial Report



Dr. Neal S. Kleiman has received clinical research funding from Bristol-Myers Squibb, Sanofi-Aventis, and Eli Lilly and Co.


  1. 1.
    Patti G, Colonna G, Pasceri V, et al.: Randomized trial of high loading dose of clopidogrel for reduction of periprocedural myocardial infarction in patients undergoing coronary intervention. Results from the ARMYDA-2 (Antiplatelet therapy for Reduction of Myocardial Damage during Angioplasty) Study. Circulation 2005, 111:2099–2106.CrossRefPubMedGoogle Scholar
  2. 2.
    Cardiobrief: ESC: CURRENT-OASIS 7 misses primary endpoint, but high dose clopidogrel aids PCI for ACS. Available at Accessed March 25, 2010.
  3. 3.
    Cannon CP, Harrington RA, James S, et al. : Comparison of ticagrelor with clopidogrel in patients with a planned invasive strategy for acute coronary syndromes (PLATO): a randomised double-blind study. Lancet 2010, 375:283–293.CrossRefPubMedGoogle Scholar
  4. 4.
    Wiviott SD, Braunwald E, McCabe CH, et al.: Prasugrel versus clopidogrel in patients with acute coronary syndromes. N Engl J Med 2007,357:2001–2015.CrossRefPubMedGoogle Scholar
  5. 5.
    Brandt JT, Payne CD, Wiviott SD, et al.: A comparison of prasugrel and clopidogrel loading doses on platelet function: magnitude of platelet inhibition is related to active metabolite formation. Am Heart J 2007, 153:66–16.CrossRefPubMedGoogle Scholar
  6. 6.
    Gurbel PA, Bliden KP, Butler K, et al.: Response to ticagrelor in clopidogrel nonresponders and responders and effect of switching therapies: the RESPOND study. Circulation 2010, 121:1188–1199.CrossRefPubMedGoogle Scholar
  7. 7.
    Mega JL, Close SL, Wiviott SD, et al.: Cytochrome p-450 polymorphisms and response to clopidogrel. N Engl J Med 2009, 360:354–362.CrossRefPubMedGoogle Scholar
  8. 8.
    Gurbel PA, Bliden KP, Butler K, et al.: Randomized double-blind assessment of the ONSET and OFFSET of the antiplatelet effects of ticagrelor versus clopidogrel in patients with stable coronary artery disease: the ONSET/OFFSET study. Circulation 2009, 120:2577–2585.CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Methodist DeBakey Heart CenterHoustonUSA

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