Current Cardiology Reports

, Volume 12, Issue 1, pp 90–97 | Cite as

Combined Anatomic and Perfusion Imaging of the Heart



Recent technological advances provided clinicians with multiple options for diagnosing and prognosticating patients with coronary artery disease (CAD). Myocardial perfusion imaging with single photon emission computed tomography and positron emission tomography is a powerful tool for assessing physiologically significant coronary atherosclerosis, but is unable to detect subclinical atherosclerosis. Coronary computed tomographic angiography permits rapid noninvasive assessment of the coronaries and demonstrates an impressive negative predictive value in the clinical literature. Nevertheless, the positive predictive value of computed tomographic angiography for clinically significant CAD is suboptimal. The combination of both of these techniques provides an opportunity to the clinician to assess for subclinical atherosclerosis (with important implications for therapy in low-intermediate risk patients) and functionally significant lesions in patients with extensive CAD. However, the application of this technology has to be implemented on a case-by-case basis to avoid unnecessary radiation exposure and cost.


Cardiac PET Cardiac CTA Perfusion imaging Subclinical atherosclerosis 

Clinical Trial Acronyms


Assessment by Coronary Computed Tomographic Angiography of Individuals Undergoing Invasive Coronary Angiography


Coronary Artery Evaluation Using 64-Row Multidetector Computed Tomography Angiography


National Health and Nutrition Surveys


Society of Cardiovascular Computed Tomography



Dr. Marcelo Di Carli has received research grants from GE, Siemens, Bracco, and Astellas. No other potential conflicts of interest relevant to this article were reported.


Papers of particular interest, published recently, have been highlighted as: •Of importance ••Of major importance

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Bilal Ali
    • 1
  • Edward Hsiao
    • 1
  • Marcelo F. Di Carli
    • 1
  1. 1.Division of Nuclear Medicine and Molecular Imaging, Department of RadiologyBrigham and Women’s HospitalBostonUSA

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