Current Cardiology Reports

, Volume 10, Issue 1, pp 37–42 | Cite as

Neuroprotection in cerebral ischemia: Emphasis on the SAINT trial

  • Marcus R. Chacon
  • Matt B. Jensen
  • Justin A. Sattin
  • Justin A. Zivin


Acute ischemic stroke (AIS) is a significant cause of death and disability in the United States. It has been 10 years since tissue plasminogen activator became the first medication approved by the US Food and Drug Administration for treatment for AIS. However, this treatment simply reopens arteries. The identification of deleterious cellular reactions that occur secondary to cerebral ischemia has led investigators to search for neuroprotection strategies to complement reperfusion. More than 100 human trials, including a handful of phase III trials, had failed to produce an efficacious neuroprotective agent. In 2006, the first positive trial of neuroprotection was published: the SAINT I (Stroke-Acute Ischemic NXY Treatment) study. In February 2008, the SAINT II study was published, indicating that NXY-059 was not effective for AIS treatment.


Cerebral Ischemia Middle Cerebral Artery Occlusion Acute Ischemic Stroke Neuroprotective Agent Nalmefene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Current Medicine Group LLC 2008

Authors and Affiliations

  • Marcus R. Chacon
  • Matt B. Jensen
  • Justin A. Sattin
    • 1
  • Justin A. Zivin
  1. 1.Department of NeurosciencesUniversity of California San DiegoLa JollaUSA

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