Fueled by dissatisfaction with pharmacologic strategies to treat atrial fbrillation (AF), the results of basic and clinical investigation into the understanding of AF initiation and maintenance mechanisms, and the explosive development in catheter-based technologies, AF ablation has matured from a purely investigational technique to a preferred, safe, and effective approach for curing AF, particularly with the circumferential approach. Future insights and developments will help us refine our treatment strategies in patients with permanent AF, making chronic AF ablation safer, faster, and more effective. As the prevalence of AF in the general population continues to increase, the purpose of optimizing our strategy becomes evermore important and more pressing.
Unable to display preview. Download preview PDF.
References and Recommended Reading
- 4.Cox JL: Cardiac surgery for arrhythmias. J Cardiovasc Electrophysiol 2004, 15:260–262.Google Scholar
- 7.Nademanee K, McKenzie J, Kosar E, et al.: A new approach for catheter ablation of atrial fbrillation: mapping of the electrophysiologic substrate. J Am Coll Cardiol 2004, 43:2044–2053. This paper tested the hypothesis that complex fractionated electrograms could be used as targets for AF ablation.PubMedCrossRefGoogle Scholar
- 8.Pappone C, Santinelli V, Manguso F, et al.: Pulmonary vein denervation enhances longterm benefit after circumferential ablation for paroxysmal AF. Circulation 2004, 109:327–334. This paper represents the first clinical documentation of additional benefit of vagal denervation on AF recurrences after AF ablation as performed in Milan.PubMedCrossRefGoogle Scholar
- 10.Scherlag BJ, Nakagawa H, Jackman W, et al.: Electrical stimulation to identify neural elements on the heart: their role in atrial fibrilation. J Interv Card Electrophysiol 2005, 13:1–6.Google Scholar