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Current Cardiology Reports

, Volume 3, Issue 1, pp 29–36 | Cite as

Clinical applications of vascular gene therapy

  • Juha Rutanen
  • Tuomas T. Rissanen
  • Antti Kivelä
  • Ismo Vajanto
  • Seppo Ylä-Herttuala
Article

Abstract

Despite significant advances in prevention, coronary artery disease remains the leading cause of death in the Western world. Surgical bypass and angioplasty are the primary interventional therapies but they are limited by the problems of restenosis and graft occlusions. Natural response to vascular occlusion involves the formation of collateral vessels that bypass obstructions, but they are often inefficient in relieving ischemia. Vascular gene transfer offers a promising new approach to solve these problems. Its potential has been shown in animal models and in first human trials using vascular endothelial growth factor, fibroblast growth factor, and E2F cell-cycle transcription factor decoy. However, further basic research on gene transfer vectors, gene delivery techniques, and identification of effective treatment genes is needed to improve the efficacy and safety of human vascular gene therapy.

Keywords

Vascular Endothelial Growth Factor Gene Therapy Gene Transfer Gene Delivery Critical Limb Ischemia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Current Science Inc. 2001

Authors and Affiliations

  • Juha Rutanen
    • 1
  • Tuomas T. Rissanen
    • 1
  • Antti Kivelä
    • 1
  • Ismo Vajanto
    • 1
  • Seppo Ylä-Herttuala
    • 1
  1. 1.A.I. Virtanen InstituteUniversity of Kuopio and Kuopio University HospitalKuopioFinland

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