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Current Bladder Dysfunction Reports

, Volume 13, Issue 4, pp 267–273 | Cite as

Shared Pathophysiology of Detrusor Overactivity and Detrusor Underactivity

  • Henry Collier Wright
  • Elizabeth Timbrook BrownEmail author
Reconstructed Bladder Function & Dysfunction (M Kaufman, Section Editor)
  • 34 Downloads
Part of the following topical collections:
  1. Topical Collection on Reconstructed Bladder Function & Dysfunction

Abstract

Purpose of Review

Detrusor overactivity (DO) and the associated symptom complex of overactive bladder (OAB) is well-studied with many treatment options. In contrast, detrusor underactivity (DU) and its associated symptom complex, underactive bladder (UAB), is poorly understood. Researchers have proposed explanations that link OAB and UAB with a common pathophysiology. The purpose of this review is to examine concepts and recent underlying research supporting a shared pathophysiology of DO and DU.

Recent Findings

In 2014, Dr. Michael Chancellor proposed “The Overactive Bladder Progression to Underactive Bladder Hypothesis.” Since then, researchers have conducted several animal and human studies to examine the pathophysiology of OAB and UAB. These studies, which highlight this shared pathophysiology, can be categorized broadly into neurogenic, myogenic, urothelial dysfunction, and idiopathic etiologies. Autonomous bladder micromotions are another proposed mechanism of shared OAB and UAB pathophysiology.

Summary

UAB is poorly understood in comparison to OAB, yet the concept of a shared pathophysiology could shed light into future research, technology, and pharmacologic interventions to adequately manage patients with these conditions.

Keywords

Underactive bladder Overactive bladder Detrusor overactivity Detrusor underactivity Pathophysiology 

Notes

Compliance with Ethical Standards

Conflict of Interest

Dr. Wright and Dr. Brown declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major Importance

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Henry Collier Wright
    • 1
  • Elizabeth Timbrook Brown
    • 1
    Email author
  1. 1.Department of UrologyMedstar Georgetown University HospitalWashingtonUSA

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