Current Atherosclerosis Reports

, Volume 1, Issue 1, pp 16–23

Treatment of dyslipidemia: Genetic interactions with diet and drug therapy

  • Jose M. Ordovas
  • Ernst J. Schaefer

DOI: 10.1007/s11883-999-0045-3

Cite this article as:
Ordovas, J.M. & Schaefer, E.J. Curr Atheroscler Rep (1999) 1: 16. doi:10.1007/s11883-999-0045-3


Coronary heart disease (CHD) is multifactorial, and its manifestation is determined by multiple gene loci and their interaction with a cohort of environmental factors. Variation at several candidate gene loci has already been shown to have a significant effect over the spectrum of plasma lipid levels observed in the population. Moreover, some variants are known to influence the interindividual variability in response to dietary and pharmacologic interventions aimed to reduce atherogenic lipoproteins. The continuous progress in this area of research is getting us closer to the development of genetic screening panels that will allow a more precise assessment of individual CHD risk and response to therapeutic interventions.

Copyright information

© Current Science Inc 1999

Authors and Affiliations

  • Jose M. Ordovas
    • 1
  • Ernst J. Schaefer
    • 1
  1. 1.Lipid Metabolism Laboratory, JM-USDA-Human Nutrition Research Center on Aging at Tufts University, Department of MedicineNew England Medical CenterBoston

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