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Perivascular Adipose Tissue and Coronary Atherosclerosis: from Biology to Imaging Phenotyping

  • Andrew Lin
  • Damini Dey
  • Dennis T. L. Wong
  • Nitesh NerlekarEmail author
Evidence-Based Medicine, Clinical Trials and Their Interpretations (L. Roever, Section Editor)
  • 97 Downloads

Abstract

Purpose of Review

Perivascular adipose tissue (PVAT) has a complex, bidirectional relationship with the vascular wall. In disease states, PVAT secretes pro-inflammatory adipocytokines which may contribute to atherosclerosis. Recent evidence demonstrates that pericoronary adipose tissue (PCAT) may also function as a sensor of coronary inflammation. This review details PVAT biology and its clinical translation to current imaging phenotyping.

Recent Findings

PCAT attenuation derived from routine coronary computed tomography (CT) angiography is a novel noninvasive imaging biomarker of coronary inflammation. Pro-inflammatory cytokines released from the arterial wall diffuse directly into the surrounding PCAT and inhibit adipocyte lipid accumulation in a paracrine manner. This can be detected as an increased PCAT CT attenuation, a metric which associates with high-risk plaque features and independently predicts cardiac mortality. There is also evidence that PCAT attenuation relates to coronary plaque progression and is modified by systemic anti-inflammatory therapies.

Summary

Due to its proximity to the coronary arteries, PCAT has emerged as an important fat depot in cardiovascular research. PCAT CT attenuation has the potential to improve cardiovascular risk stratification, and future clinical studies should examine its role in guiding targeted medical therapy.

Keywords

Perivascular adipose tissue Atherosclerosis Inflammation Cardiac computed tomography angiography 

Notes

Funding information

Dr Nerlekar is supported by a post-doctoral scholarship from the National Heart Foundation and a Robertson Family Research Fellowship. Dr. Dey is supported in part by a National Heart, Lung, and Blood Institute grant 1R01HL133616.

Compliance with Ethical Standards

Conflict of Interest

Andrew Lin, Damini Dey, Dennis T.L. Wong, and Nitesh Nerlekar declare they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Andrew Lin
    • 1
    • 2
    • 3
  • Damini Dey
    • 3
  • Dennis T. L. Wong
    • 1
    • 2
  • Nitesh Nerlekar
    • 1
    • 2
    Email author
  1. 1.Monash Cardiovascular Research CentreMonash University and MonashHeart, Monash HealthClaytonAustralia
  2. 2.Department of MedicineMonash UniversityClaytonAustralia
  3. 3.Biomedical Imaging Research InstituteCedar-Sinai Medical CentreLos AngelesUSA

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