Is there Sufficient Enhancement of the Reduction in CVD Rates after a Decade of Statin Therapy to Justify Continuation?

Statin Drugs (MB Clearfield, Section Editor)

DOI: 10.1007/s11883-014-0432-2

Cite this article as:
Soverow, J. & Watson, K. Curr Atheroscler Rep (2014) 16: 432. doi:10.1007/s11883-014-0432-2
  • 335 Downloads
Part of the following topical collections:
  1. Topical Collection on Statin Drugs

Abstract

Randomized, controlled clinical trials have shown significant benefits of statin therapy in patients with or at risk for atherosclerotic cardiovascular disease (ASCVD). But these trials typically enroll patients for only 5 years or so, prompting some clinicians to ask what the longer term follow-up of these patients will show. While most trials have a duration of only approximately 5 years, four large trials report extended post-trial follow-up to 10 years, and these trials, as well as multiple large cohort studies, suggest an expected benefit of statins’ effects beyond 10 years. In this review we will summarize the current state of the literature, the benefits noted to date, and the potentially accumulating, adverse effects of long-term statin use.

Keywords

Statin therapy Long-term statin use Statin duration 

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Division of CardiologyUCLA Medical CenterLos AngelesUSA

Personalised recommendations