Endothelial Dysfunction: Its Clinical Value and Methods of Assessment

  • Teresa Strisciuglio
  • Stefania De Luca
  • Ernesto Capuano
  • Rossella Luciano
  • Tullio Niglio
  • Bruno Trimarco
  • Gennaro Galasso
Cardiovascular Disease and Stroke (P Perrone-Filardi and S. Agewall, Section Editors)
Part of the following topical collections:
  1. Topical Collection on Cardiovascular Disease and Stroke


Endothelial dysfunction (ED) is a systemic disorder characterized by reduced production of nitric oxide. This pathologic condition, which impairs vascular homeostasis, leads to the loss of protective properties of endothelial cells and is related to the pathogenesis of cardiovascular diseases. ED may affect every vascular bed, accounting for several clinical implications, particularly when the coronary bed is affected. Although the reliability of ED as a cardiovascular disease surrogate is still debated, many methods for its assessment have been proposed. In this review, we underline the clinical value of ED in the cardiovascular field and summarize the principal methods currently available for its assessment.


Coronary artery disease Endothelial dysfunction Flow mediated dilation Pulse amplitude tonometry 


Compliance with Ethics Guidelines

Conflict of Interest

Teresa Strisciuglio, Stefania De Luca, Ernesto Capuano, Rossella Luciano, Tullio Niglio, Bruno Trimarco, and Gennaro Galasso declare that they have no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Teresa Strisciuglio
    • 1
  • Stefania De Luca
    • 1
  • Ernesto Capuano
    • 1
  • Rossella Luciano
    • 1
  • Tullio Niglio
    • 1
  • Bruno Trimarco
    • 1
  • Gennaro Galasso
    • 1
  1. 1.Department of Advanced Biomedical SciencesUniversity of Naples Federico IINaplesItaly

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