Stroke and Obstructive Sleep Apnea: A Review

  • Daniel A. Barone
  • Ana C. KriegerEmail author
Cardiovascular Disease and Stroke (D Leifer and JE Safdieh, Section Editors)
Part of the following topical collections:
  1. Topical Collection on Cardiovascular Disease and Stroke


Obstructive sleep apnea (OSA) has been found to be an independent risk factor for stroke in large epidemiological studies. The mechanisms underlying this relationship have been investigated over the past 2–3 decades, with a particular focus on identifying pathophysiological pathways and risk modification strategies. Despite the advancements made, the specific understanding of the implicated mechanisms is still limited. This brief review focuses on presenting some of the epidemiological evidence of the linkage between OSA and stroke, discussing mechanistic pathways and the potential effect of OSA treatment in modulating the risk for stroke in these patients. Future directions for research in this field are also discussed.


Stroke Sleep apnea Obstructive sleep apnea Thrombosis Cardiovascular disease Cerebrovascular disease 


Conflict of Interest

Daniel A. Barone declares that he has no conflicts of interest.

Ana C. Krieger declares that she has no conflicts of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.


Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of Neurology, Weill Cornell Medical College Center for Sleep MedicineCornell UniversityNew YorkUSA
  2. 2.Departments of Medicine, Neurology and Genetic Medicine, Weill Cornell Medical College Center for Sleep MedicineCornell UniversityNew YorkUSA

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