Current Atherosclerosis Reports

, Volume 14, Issue 1, pp 60–69 | Cite as

Advances in Medical Therapy for Weight Loss and the Weight-Centric Management of Type 2 Diabetes Mellitus

  • Leon I. Igel
  • Amanda G. Powell
  • Caroline M. Apovian
  • Louis J. AronneEmail author
Nonstatin Drugs (W Borden, Section Editor)


Overweight and obesity are now recognized as leading causes of diseases such as type 2 diabetes, hypertension, hyperlipidemia, and ultimately, cardiovascular disease. Despite the serious consequences, roughly two thirds of Americans are presently classified as overweight, and about one third are classified as obese. Weight loss via lifestyle modification and pharmacotherapy can promote improvement in many of these obesity-related conditions. This review addresses recent advances in pharmacotherapy for the management of obesity and obesity-related co-morbidities, with a focus on the management of obesity specifically in individuals with type 2 diabetes. Emphasis is also placed on a proposed paradigm shift from the glucose-centric to the weight-centric management of type 2 diabetes mellitus.


Weight loss Weight management Obesity Type 2 diabetes Pharmacotherapy Glycemic control Weight-centric management of type 2 diabetes 



L.I. Igel: none. A.G. Powell: none. C.M. Apovian is a paid advisory board member for Amylin, Merck, Johnson and Johnson, Abbott, Sanofi-Aventis, Allergan, Orexigen, and Arena; has provided expert testimony for Allergan and Orexigen; and has received grants from the Atkins Foundation, Amylin, and MetaProteomics. L.J. Aronne is a paid scientific advisory board member for and has had travel expenses reimbursed by Orexigen, Ethicon Endo-Surgery, Novo Nordisk, VIVUS, Amylin, Pfizer, Sanofi-Aventis, Merck, and Johnson and Johnson; is a consultant for NeuroSearch, Takeda, GlaxoSmithKline, Abbott, Wyeth, and Allergan; has provided expert testimony for VIVUS; has received grants from Orexigen, Novo Nordisk, Amylin, F. Hoffman-La Roche, Pfizer, Merck, Arena, VIVUS, Schering-Plough, TransTech Pharma, MetaCure, and Metabolous Pharmaceuticals; and owns stock/stock options in Atlas Therapeutics and Cardiometabolic Support Network.


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Leon I. Igel
    • 1
  • Amanda G. Powell
    • 2
  • Caroline M. Apovian
    • 3
  • Louis J. Aronne
    • 4
    Email author
  1. 1.Department of MedicineNew York Presbyterian/Weill Cornell Medical CenterNew YorkUSA
  2. 2.Division of Endocrinology, Diabetes and Nutrition, Department of MedicineBoston University School of MedicineBostonUSA
  3. 3.Division of Endocrinology, Diabetes and Nutrition, Department of MedicineBoston University School of MedicineBostonUSA
  4. 4.Department of MedicineWeill Cornell Medical College, Comprehensive Weight Control Program, New York-Presbyterian HospitalNew YorkUSA

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