Genetics of Redox Systems and Their Relationship with Cardiovascular Disease
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As atherosclerosis is still one of the major causes of death in Western populations, it is important to identify those individuals who are at increased risk for the disease so that aggressive treatment may be administered as early as possible. Following the understanding that oxidative stress has a pivotal role in the development and progression of atherosclerosis, many polymorphisms in genes that are related to redox systems were examined for their association with increased risk for cardiovascular disease (CVD). Although many polymorphisms were studied, only a handful showed consistent relevance to CVD in different trials. This article focuses on six of these polymorphisms, examining their effect on the risk for CVD as well as their effect on protein expression and function. Reports regarding pharmacogenetic implications of these polymorphisms, where such exist, are discussed as well.
KeywordsCardiovascular disease CVD Redox Genetics Oxidative stress Vitamins
This work was supported by grants from the Israel-US Binational Science Foundation, the Juvenile Diabetes Foundation, and the National Institutes of Health (NIH RO1DK085226).
All of the authors have received grants to their institution from the National Institutes of Health and the Juvenile Diabetes Research Foundation.
Papers of particular interest, published recently, have been highlighted as: • Of importance
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