Current Atherosclerosis Reports

, Volume 12, Issue 4, pp 259–266

Novel Genetic Mechanisms for Aortic Aneurysms

  • Gerard Tromp
  • Helena Kuivaniemi
  • Irene Hinterseher
  • David J. Carey
Article

Abstract

Aortic aneurysms occur in the thoracic and abdominal sections of the aorta and are a deadly late-age-at-onset disease with complex pathobiology. Currently, the number of published genome-wide analyses including microarray-based expression profiling, DNA linkage studies, and genetic association studies is still limited and it is difficult to make generalizations about the disease pathogenesis or genetic risk factors contributing to aortic aneurysms, but it appears that thoracic aortic aneurysms differ in many ways from abdominal aortic aneurysms. Characterization of diseases at the molecular level is likely to lead to more accurate diagnoses and the use of “genomic nosology” of disease. The biggest future challenge will be to translate the genomic information to the clinic and improve our understanding of the disease processes, help us to develop better diagnostic tools, and lead to the design of new ways to manage aortic aneurysms in the era of personalized medicine.

Keywords

Aorta Aneurysm Embryology Embryologic origin Genetic risk factor DNA linkage analysis Genetic association study Sciatic artery Losartan Genomic nosology Abdominal aortic aneurysm Thoracic aortic aneurysm ANRIL Transforming growth factor-beta 

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Gerard Tromp
    • 1
  • Helena Kuivaniemi
    • 1
  • Irene Hinterseher
    • 1
  • David J. Carey
    • 1
  1. 1.Sigfried and Janet Weis Center for ResearchGeisinger ClinicDanvilleUSA

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