Current Atherosclerosis Reports

, Volume 12, Issue 3, pp 202–208 | Cite as

Proteomic and Metabolomic Profiles in Atherothrombotic Vascular Disease

  • Roxana Martinez-Pinna
  • Coral Barbas
  • Luis Miguel Blanco-Colio
  • Jose Tunon
  • Priscila Ramos-Mozo
  • Juan Antonio Lopez
  • Olivier Meilhac
  • Jean-Baptiste Michel
  • Jesus Egido
  • José Luis Martin-Ventura
Article

Abstract

Atherothrombosis remains a major cause of morbidity and mortality in the western world. The underlying processes associated with clinical expression of atherothrombosis include oxidative stress and proteolysis in relation to neovascularisation and intraplaque hemorrhages, leading to immuno-inflammatory response, cell death, and extracellular matrix breakdown. The complex biological multifactorial nature of atherothrombosis requires the development of novel technologies that allow the analysis of cellular and molecular processes responsible for the transition to disease phenotypes and the discovery of new diagnostic and prognostic biomarkers. In the present article, we have reviewed recent advances in the application of proteomic and metabolomic techniques to the study of atherothrombosis. We have focused on recent studies analyzing cells involved in hemo-thrombus formation (platelets, red blood cells, and polymorphonuclear cells), as well as tissues, tissue-conditioned media, and plasma of atherothrombotic patients. In the future, the application of these high-throughput technologies, along with imaging techniques, in systems biology approaches will help to individualize medicine.

Keywords

Proteomics Metabolomics Biomarkers Atherosclerosis Abdominal aortic aneurysm 

Notes

Acknowledgments

The papers from the authors cited in the present review have been supported by European Network (HEALTH F2-2008-200647), SAF 2007/63648, SAF2007/60896, CAM (S2006/GEN-0247), Fundación Ramón Areces, Ministerio de Sanidad y Consumo, Instituto de Salud Carlos III, Red RECAVA (RD06/0014/0035), Fondo de Investigaciones Sanitarias (Programa Miguel Servet to L.M.B-C). The Centro Nacional de Investigaciones Cardiovasculares (CNIC) is supported by MICINN and Pro CNIC Foundation.

Disclosure

No potential conflicts of interest relevant to this article were reported.

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Roxana Martinez-Pinna
    • 1
  • Coral Barbas
    • 2
  • Luis Miguel Blanco-Colio
    • 1
  • Jose Tunon
    • 3
  • Priscila Ramos-Mozo
    • 1
  • Juan Antonio Lopez
    • 4
  • Olivier Meilhac
    • 5
  • Jean-Baptiste Michel
    • 5
  • Jesus Egido
    • 1
  • José Luis Martin-Ventura
    • 1
  1. 1.Vascular Research Laboratory, Instituto de Investigacion Sanitaria, Fundación Jimenez DiazAutonoma UniversityMadridSpain
  2. 2.Pharmacy Faculty, Campus MonteprincipeSan Pablo-CEU UniversityMadridSpain
  3. 3.Department of Cardiology, Instituto de Investigaciones Sanitarias, Fundación Jimenez DiazAutonoma UniversityMadridSpain
  4. 4.Unidad de Proteomica, Centro Nacional de Investigaciones Cardiovasculares (CNIC)MadridSpain
  5. 5.Inserm, U698, Univ Paris 7, CHU X-BichatParisFrance

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