Intakes of long-chain omega-3 fatty acid associated with reduced risk for death from coronary heart disease in healthy adults
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Numerous organizations and national health agencies have begun to recommend consumption of the long-chain omega-3 fatty acids (FAs) eicosapentaenoic acid and docosahexaenoic acid (EPA and DHA), respectively, in pill or fish form for general cardiovascular health. The purpose of this article is to present a rationale for an official target intake of 400 to 500 mg/d of EPA + DHA in the United States. Six epidemiologic studies reporting EPA + DHA intake and risk of coronary heart disease (CHD) death have been conducted in the United States, and five studies reported statistically significant inverse trends. Meta-analysis of these data showed a significant dose-response relationship between risk for CHD death and intake (P = 0.03), with relative risk reductions of 37% at an average EPA + DHA intake of 566 mg/d. Coincidentally, two servings per week of oily fish (the current American Heart Association recommendation) would provide 400 to 500 mg/d. We conclude, therefore, that an intake of 400 to 500 mg/d of EPA + DHA is achievable by diet alone and would be expected to significantly reduce risk for death from CHD in healthy adults.
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References and Recommended Reading
- 11.Dolecek TA: Epidemiological evidence of relationships between dietary polyunsaturated fatty acids and mortality in the Multiple Risk Factor Intervention Trial. Proc Soc Exper Bio Med 1992, 200:177–182.Google Scholar
- 19.von Schacky C, Angerer P, Kothny W, et al.: The effect of dietary w-3 fatty acids on coronary atherosclerosis. a randomized, double-blind, placebo-controlled trial. Ann Intern Med 1999, 130:554–562.Google Scholar
- 26.Marchioli R, Barzi F, Bomba E, et al.: Early protection against sudden death by n-3 polyunsaturated fatty acids after myocardial infarction: time-course analysis of the results of the Gruppo Italiano per lo Studio della Sopravvivenza nell’Infarto Miocardico (GISSI)-Prevenzione. Circulation 2002, 105:1897–1903.PubMedCrossRefGoogle Scholar
- 27.United States Department of Agriculture: Foods commonly eaten in the United States. Available at: http://www.ars.usda.gov/SP2UserFiles/Place/12355000/pdf/Portion.pdf. Accessed on May 27, 2008.
- 28.Food Standards Agency: Advice on fish consumption: benefits and risks. Available at: http://www.food.gov.uk/news/newsarchive/2004/jun/fishreport2004. Accessed on May 27, 2008.
- 29.Health Council of the Netherlands: Guidelines for a healthy diet 2006. Available at http://www.gr.nl/samenvatting.php?ID=1481. Accessed on May 27, 2008.
- 35.Food and Drug Administration: Substances affirmed as generally recognized as safe: Menhaden Oil. Fed Regist 1997, 30751–30757.Google Scholar
- 37.Food and Drug Administration: Guidance on mercury. Available at http://www.fda.gov/oc/opacom/mehgadvisory1208.html. Accessed on May 27, 2008.
- 39.Eurodiet Core Report 2000. Available at http://eurodiet.med.uoc.gr/eurodietcorereport.pdf. Accessed on May 27, 2008.
- 40.AFFSA: Apports Nutritionnels Conseilles (ANC). In Apports Nutritionnels Conseilles pour la Population Franąise, edn 3. Edited by Martin A. Lavoisier, France: Tech. & Doc; 2001.Google Scholar
- 41.International Society for the Study of Fatty Acids and Lipids, 2004: Statement on essential fatty acid intakes. Available at http://www.issfal.org.uk/lipid-matters/issfal-policy-statements/issfal-policy-statement-3-2.html. Accessed on May 27, 2008.
- 42.National Health and Medical Research Council: Nutrient reference values for Australia and New Zealand, 2005. Available at http://www.nhmrc.gov.au/publications/synopses/n35syn.htm. Accessed on May 27, 2008.
- 43.Superior Health Council of Belgium: Advisory Report. Recommendations and claims made on omega-3 fatty acids, 2006. Available at: https://portal.health.fgov.be/pls/portal/docs/PAGE/INTERNET_PG/HOMEPAGE_MENU/ABOUTUS1_MENU/INSTITUTIONSAPPARENTEES1_MENU/HOGEGEZONDHEIDSRAAD1_MENU/ADVIEZENENAANBEVELINGEN1_MENU/ADVIEZENENAANBEVELINGEN1_DOCS/HGR7145-2_VOEDINGSAANBEVELINGEN_2006_NL.PDF. Accessed on May 27, 2008.