Current Atherosclerosis Reports

, Volume 10, Issue 6, pp 460–466 | Cite as

Saturated and trans fatty acids and coronary heart disease

  • Jayne V. Woodside
  • Michelle C. McKinley
  • Ian S. Young


Dietary intake of both saturated and trans fatty acids has been associated with an increase in the risk of coronary heart disease (CHD). Evidence comes mainly from controlled dietary experiments with intermediate end points, such as blood lipoproteins, and from observational studies. A few small, randomized controlled trials with clinical end points have been carried out in which saturated fat was replaced with polyunsaturated fat, leading to a reduction in low-density lipoprotein cholesterol and a reduction in CHD risk. However, no such studies exist for trans fatty acids. More high-quality, randomized controlled trials on fatty acids and CHD are required, but public health recommendations to reduce intake of both saturated and trans fatty acids are appropriate based on the current evidence.


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Copyright information

© Current Medicine Group LLC 2008

Authors and Affiliations

  • Jayne V. Woodside
    • 1
  • Michelle C. McKinley
  • Ian S. Young
  1. 1.Nutrition and Metabolism Group, Centre for Clinical and Population ScienceQueen’s University BelfastBelfastUK

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