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Current Atherosclerosis Reports

, Volume 7, Issue 6, pp 455–459 | Cite as

Influence of dietary carbohydrate and fat on LDL and HDL particle distributions

  • Patty W. Siri
  • Ronald M. Krauss
Article

Abstract

Variations in the size and density distributions of low-density lipoprotein (LDL) and high-density lipoprotein (HDL) particles have been related to risk for cardiovascular disease. In particular, increased levels of small, dense LDL particles, together with reduced levels of large HDL and increases in small HDL, are integral features of the atherogenic dyslipidemia found in patients with insulin resistance, obesity, and metabolic syndrome. Increased dietary carbohydrates, particularly simple sugars and starches with high glycemic index, can increase levels of small, dense LDL and HDL, primarily by mechanisms that involve increasing plasma triglyceride concentrations. Low-carbohydrate diets may have the opposite effects. Diets with differing fatty acid composition can also influence LDL and HDL particle distributions.

Keywords

High Density Lipoprotein Cholesterol Trans Fatty Acid High Density Lipoprotein Cholesterol Level Atherogenic Dyslipidemia High Density Lipoprotein Particle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Berneis KK, Krauss RM: Metabolic origins and clinical significance of LDL heterogeneity. J Lipid Res 2002, 43:1363–1379.PubMedCrossRefGoogle Scholar
  2. 2.
    Reaven GM, Chen YD, Jeppesen J, et al.: Insulin resistance and hyperinsulinemia in individuals with small, dense low density lipoprotein particles. J Clin Invest 1993, 92:141–146.PubMedGoogle Scholar
  3. 3.
    Grundy SM: Small LDL, atherogenic dyslipidemia, and the metabolic syndrome. Circulation 1997, 95:1–4.PubMedGoogle Scholar
  4. 4.
    Austin MA, King MC, Vranizan KM, Krauss RM: Atherogenic lipoprotein phenotype. A proposed genetic marker for coronary heart disease risk. Circulation 1990, 82:495–506.PubMedGoogle Scholar
  5. 5.
    McNamara JR, Campos H, Ordovas JM, et al.: Effect of gender, age, and lipid status on low density lipoprotein subfraction distribution. Results from the Framingham Offspring Study. Arteriosclerosis 1987, 7:483–490.PubMedGoogle Scholar
  6. 6.
    McNamara JR, Jenner JL, Li Z, et al.: Change in LDL particle size is associated with change in plasma triglyceride concentration. Arterioscler Thromb 1992, 12:1284–1290.PubMedGoogle Scholar
  7. 7.
    Lewis GF, Rader DJ: New insights into the regulation of HDL metabolism and reverse cholesterol transport. Circ Res 2005, 96:1221–1232.PubMedCrossRefGoogle Scholar
  8. 8.
    Hopkins GJ, Barter PJ: Role of triglyceride-rich lipoproteins and hepatic lipase in determining the particle size and composition of high density lipoproteins. J Lipid Res 1986, 27:1265–1277.PubMedGoogle Scholar
  9. 9.
    Rashid S, Watanabe T, Sakaue T, Lewis GF: Mechanisms of HDL lowering in insulin resistant, hypertriglyceridemic states: the combined effect of HDL triglyceride enrichment and elevated hepatic lipase activity. Clin Biochem 2003, 36:421–429.PubMedCrossRefGoogle Scholar
  10. 10.
    Brinton EA, Eisenberg S, Breslow JL: Increased apo A-I and apo A-II fractional catabolic rate in patients with low high density lipoprotein-cholesterol levels with or without hypertriglyceridemia. J Clin Invest 1991, 87:536–544.PubMedGoogle Scholar
  11. 11.
    Brinton EA, Eisenberg S, Breslow JL: Elevated high density lipoprotein cholesterol levels correlate with decreased apolipoprotein A-I and A-II fractional catabolic rate in women. J Clin Invest 1989, 84:262–269.PubMedGoogle Scholar
  12. 12.
    Brinton EA, Eisenberg S, Breslow JL: Human HDL cholesterol levels are determined by apoA-I fractional catabolic rate, which correlates inversely with estimates of HDL particle size. Effects of gender, hepatic and lipoprotein lipases, triglyceride and insulin levels, and body fat distribution. Arterioscler Thromb 1994, 14:707–720.PubMedGoogle Scholar
  13. 13.
    Ooi EM, Watts GF, Farvid MS, et al.: High-density Lipoprotein Apolipoprotein A-I Kinetics in Obesity. Obes Res 2005, 13:1008–1016.PubMedGoogle Scholar
  14. 14.
    La Belle M, Krauss RM: Differences in carbohydrate content of low density lipoproteins associated with low density lipoprotein subclass patterns. J Lipid Res 1990, 31:1577–1588.PubMedGoogle Scholar
  15. 15.
    Lund-Katz S, Laplaud PM, Phillips MC, Chapman MJ: Apolipoprotein B-100 conformation and particle surface charge in human LDL subspecies: implication for LDL receptor interaction. Biochemistry 1998, 37:12867–12874.PubMedCrossRefGoogle Scholar
  16. 16.
    McNamara JR, Small DM, Li Z, Schaefer EJ: Differences in LDL subspecies involve alterations in lipid composition and conformational changes in apolipoprotein B. J Lipid Res 1996, 37:1924–1935.PubMedGoogle Scholar
  17. 17.
    Nigon F, Lesnik P, Rouis M, Chapman MJ: Discrete subspecies of human low density lipoproteins are heterogeneous in their interaction with the cellular LDL receptor. J Lipid Res 1991, 32:1741–1753.PubMedGoogle Scholar
  18. 18.
    Campos H, Arnold KS, Balestra ME, et al.: Differences in receptor binding of LDL subfractions. Arterioscler Thromb Vasc Biol 1996, 16:794–801.PubMedGoogle Scholar
  19. 19.
    Bjornheden T, Babyi A, Bondjers G, Wiklund O: Accumulation of lipoprotein fractions and subfractions in the arterial wall, determined in an in vitro perfusion system. Atherosclerosis 1996, 123:43–56.PubMedCrossRefGoogle Scholar
  20. 20.
    Chait A, Brazg RL, Tribble DL, Krauss RM: Susceptibility of small, dense, low-density lipoproteins to oxidative modification in subjects with the atherogenic lipoprotein phenotype, pattern B. Am J Med 1993, 94:350–356.PubMedCrossRefGoogle Scholar
  21. 21.
    Blanche PJ, Gong EL, Forte TM, Nichols AV: Characterization of human high-density lipoproteins by gradient gel electrophoresis. Biochim Biophys Acta 1981, 665:408–419.PubMedGoogle Scholar
  22. 22.
    Williams PT, Dreon DM, Krauss RM: Effects of dietary fat on high-density-lipoprotein subclasses are influenced by both apolipoprotein E isoforms and low-density-lipoprotein subclass patterns. Am J Clin Nutr 1995, 61:1234–1240.PubMedGoogle Scholar
  23. 23.
    Pascot A, Lemieux I, Prud’homme D, et al.: Reduced HDL particle size as an additional feature of the atherogenic dyslipidemia of abdominal obesity. J Lipid Res 2001, 42:2007–2014.PubMedGoogle Scholar
  24. 24.
    Festa A, Williams K, Hanley AJ, et al.: Nuclear magnetic resonance lipoprotein abnormalities in prediabetic subjects in the Insulin Resistance Atherosclerosis Study. Circulation 2005, 111:3465–3472.PubMedCrossRefGoogle Scholar
  25. 25.
    Krauss RM, Williams PT, Lindgren FT, Wood PD: Coordinate changes in levels of human serum low and high density lipoprotein subclasses in healthy men. Arteriosclerosis 1988, 8:155–162.PubMedGoogle Scholar
  26. 26.
    Campos H, Willett WC, Peterson RM, et al.: Nutrient intake comparisons between Framingham and rural and Urban Puriscal, Costa Rica. Associations with lipoproteins, apolipoproteins, and low density lipoprotein particle size. Arterioscler Thromb 1991, 11:1089–1099.PubMedGoogle Scholar
  27. 27.
    Dreon DM, Fernstrom HA, Miller B, Krauss RM: Low-density lipoprotein subclass patterns and lipoprotein response to a reduced-fat diet in men. FASEB J 1994, 8:121–126.PubMedGoogle Scholar
  28. 28.
    Krauss RM, Dreon DM: Low-density-lipoprotein subclasses and response to a low-fat diet in healthy men. Am J Clin Nutr 1995, 62:478S-487S.PubMedGoogle Scholar
  29. 29.
    Krauss RM: Dietary and genetic effects on low-density lipoprotein heterogeneity. Annu Rev Nutr 2001, 21:283–295.PubMedCrossRefGoogle Scholar
  30. 30.
    Parks EJ, Hellerstein MK: Carbohydrate-induced hypertriacylglycerolemia: historical perspective and review of biological mechanisms. Am J Clin Nutr 2000, 71:412–433.PubMedGoogle Scholar
  31. 31.
    Ordovas JM: The genetics of serum lipid responsiveness to dietary interventions. Proc Nutr Soc 1999, 58:171–187.PubMedCrossRefGoogle Scholar
  32. 32.
    Schaefer EJ, Lamon-Fava S, Ausman LM, et al.: Individual variability in lipoprotein cholesterol response to National Cholesterol Education Program Step 2 diets. Am J Clin Nutr 1997, 65:823–830.PubMedGoogle Scholar
  33. 33.
    Dreon DM, Fernstrom HA, Williams PT, Krauss RM: LDL subclass patterns and lipoprotein response to a low-fat, high-carbohydrate diet in women. Arterioscler Thromb Vasc Biol 1997, 17:707–714.PubMedGoogle Scholar
  34. 34.
    Parks EJ, Krauss RM, Christiansen MP, et al.: Effects of a low-fat, high-carbohydrate diet on VLDL-triglyceride assembly, production, and clearance. J Clin Invest 1999, 104:1087–1096.PubMedGoogle Scholar
  35. 35.
    Hudgins LC, Hellerstein MK, Seidman CE, et al.: Relationship between carbohydrate-induced hypertriglyceridermia and fatty acid synthesis in lean and obese subjects. J Lipid Res 2000, 41:595–604.PubMedGoogle Scholar
  36. 36.
    Brinton EA, Eisenberg S, Breslow JL: A low-fat diet decreases high density lipoprotein (HDL) cholesterol levels by decreasing HDL apolipoprotein transport rates. J Clin Invest 1990, 85:144–151.PubMedCrossRefGoogle Scholar
  37. 37.
    Lichtenstein AH, Ausman LM, Carrasco W, et al.: Short-term consumption of a low-fat diet beneficially affects plasma lipid concentrations only when accompanied by weight loss. Hypercholesterolemia, low-fat diet, and plasma lipids. Arterioscler Thromb 1994, 14:1751–1760.PubMedGoogle Scholar
  38. 38.
    Schaefer EJ, Lichtenstein AH, Lamon-Fava S, et al.: Body weight and low-density lipoprotein cholesterol changes after consumption of a low-fat ad libitum diet. JAMA 1995, 274:1450–1455.PubMedCrossRefGoogle Scholar
  39. 39.
    Krauss R: unpublished data. 2005.Google Scholar
  40. 40.
    Brand-Miller JC: Glycemic load and chronic disease. Nutr Rev 2003, 61(5 Pt 2):S49-S55.PubMedCrossRefGoogle Scholar
  41. 41.
    Dumesnil JG, Turgeon J, Tremblay A, et al.: Effect of a low-glycaemic index—low-fat—high protein diet on the atherogenic metabolic risk profile of abdominally obese men. Br J Nutr 2001, 86:557–568.PubMedGoogle Scholar
  42. 42.
    Slyper A, Jurva J, Pleuss J, et al.: Influence of glycemic load on HDL cholesterol in youth. Am J Clin Nutr 2005, 81:376–379.PubMedGoogle Scholar
  43. 43.
    Luscombe ND, Noakes M, Clifton PM: Diets high and low in glycemic index versus high monounsaturated fat diets: effects on glucose and lipid metabolism in NIDDM. Eur J Clin Nutr 1999, 53:473–478.PubMedCrossRefGoogle Scholar
  44. 44.
    Garg A, Bonanome A, Grundy SM, et al.: comparison of a high-carbohydrate diet with a high-monounsaturated-fat diet in patients with non-insulin-dependent diabetes mellitus. N Engl J Med 1988, 319:829–834.PubMedGoogle Scholar
  45. 45.
    Kasim-Karakas SE, Almario RU, Mueller WM, Peerson J: Changes in plasma lipoproteins during low-fat, high-carbohydrate diets: effects of energy intake. Am J Clin Nutr 2000, 71:1439–1447.PubMedGoogle Scholar
  46. 46.
    Katan MB, Zock PL, Mensink RP: Effects of fats and fatty acids on blood lipids in humans: an overview. Am J Clin Nutr 1994, 60(Suppl 6):1017S-1022S.PubMedGoogle Scholar
  47. 47.
    Mensink RP, Katan MB: Effect of dietary fatty acids on serum lipids and lipoproteins. A meta-analysis of 27 trials. Arterioscler Thromb 1992, 12:911–919.PubMedGoogle Scholar
  48. 48.
    Dreon DM, Fernstrom HA, Campos H, et al.: Change in dietary saturated fat intake is correlated with change in mass of large low-density-lipoprotein particles in men. Am J Clin Nutr 1998, 67:828–836.PubMedGoogle Scholar
  49. 49.
    Dietschy JM: Dietary fatty acids and the regulation of plasma low density lipoprotein cholesterol concentrations. J Nutr 1998, 128(Suppl 2):444S-448S.PubMedGoogle Scholar
  50. 50.
    Krauss RM: Hold the antioxidants and improve plasma lipids? J Clin Invest 2004, 113:1253–1255.PubMedCrossRefGoogle Scholar
  51. 51.
    Grande F, Anderson JT, Keys A: Comparison of effects of palmitic and stearic acids in the diet on serum cholesterol in man. Am J Clin Nutr 1970, 23:1184–1193.PubMedGoogle Scholar
  52. 52.
    Hegsted DM, McGandy RB, Myers ML, Stare FJ: Quantitative effects of dietary fat on serum cholesterol in man. Am J Clin Nutr 1965, 17:281–295.PubMedGoogle Scholar
  53. 53.
    Ashton EL, Best JD, Ball MJ: Effects of monounsaturated enriched sunflower oil on CHD risk factors including LDL size and copper-induced LDL oxidation. J Am Coll Nutr 2001, 20:320–326.PubMedGoogle Scholar
  54. 54.
    Rivellese AA, Maffettone A, Vessby B, et al.: Effects of dietary saturated, monounsaturated and n-3 fatty acids on fasting lipoproteins, LDL size and post-prandial lipid metabolism in healthy subjects. Atherosclerosis 2003, 167:149–158.PubMedCrossRefGoogle Scholar
  55. 55.
    Khan S, Minihane AM, Talmud PJ, et al.: Dietary long-chain n-3 PUFAs increase LPL gene expression in adipose tissue of subjects with an atherogenic lipoprotein phenotype. J Lipid Res 2002, 43:979–985.PubMedGoogle Scholar
  56. 56.
    Callow J, Summers LK, Bradshaw H, Frayn KN: Changes in LDL particle composition after the consumption of meals containing different amounts and types of fat. Am J Clin Nutr 2002, 76:345–350.PubMedGoogle Scholar
  57. 57.
    Schaefer EJ, Lichtenstein AH, Lamon-Fava S, et al.: Effects of National Cholesterol Education Program Step 2 diets relatively high or relatively low in fish-derived fatty acids on plasma lipoproteins in middle-aged and elderly subjects. Am J Clin Nutr 1996, 63:234–241.PubMedGoogle Scholar
  58. 58.
    Suzukawa M, Abbey M, Howe PR, Nestel PJ: Effects of fish oil fatty acids on low density lipoprotein size, oxidizability, and uptake by macrophages. J Lipid Res 1995, 36:473–484.PubMedGoogle Scholar
  59. 59.
    Griffin BA: The effect of n-3 fatty acids on low density lipoprotein subfractions. Lipids 2001, 36(Suppl):S91-S97.PubMedCrossRefGoogle Scholar
  60. 60.
    Rader DJ: Effects of nonstatin lipid drug therapy on high-density lipoprotein metabolism. Am J Cardiol 2003, 91(7A):18E-23E.PubMedCrossRefGoogle Scholar
  61. 61.
    Harris WS: n-3 fatty acids and lipoproteins: comparison of results from human and animal studies. Lipids 1996, 31:243–252.PubMedCrossRefGoogle Scholar
  62. 62.
    Thomas TR, Smith BK, Donahue OM, et al.: Effects of omega-3 fatty acid supplementation and exercise on low-density lipoprotein and high-density lipoprotein subfractions. Metabolism 2004, 53:749–754.PubMedCrossRefGoogle Scholar
  63. 63.
    Lu G, Windsor SL, Harris WS: Omega-3 fatty acids alter lipoprotein subfraction distributions and the in vitro conversion of very low density lipoproteins to low density lipoproteins. J Nutr Biochem 1999, 10:151–158.PubMedCrossRefGoogle Scholar
  64. 64.
    Calabresi L, Villa B, Canavesi M, et al.: An omega-3 polyunsaturated fatty acid concentrate increases plasma high-density lipoprotein 2 cholesterol and paraoxonase levels in patients with familial combined hyperlipidemia. Metabolism 2004, 53:153–158.PubMedCrossRefGoogle Scholar
  65. 65.
    Lichtenstein AH, Ausman LM, Jalbert SM, Schaefer EJ: Effects of different forms of dietary hydrogenated fats on serum lipoprotein cholesterol levels. N Engl J Med 1999, 340:1933–1940.PubMedCrossRefGoogle Scholar
  66. 66.
    Nestel P, Noakes M, Belling B, et al.: Plasma lipoprotein lipid and Lp[a] changes with substitution of elaidic acid for oleic acid in the diet. J Lipid Res 1992, 33:1029–1036.PubMedGoogle Scholar
  67. 67.
    Ascherio A, Katan MB, Zock PL, et al.: Trans fatty acids and coronary heart disease. N Engl J Med 1999, 340:1994–1998.PubMedCrossRefGoogle Scholar
  68. 68.
    Kim MK, Campos H: Intake of trans fatty acids and low-density lipoprotein size in a Costa Rican population. Metabolism 2003, 52:693–698.PubMedCrossRefGoogle Scholar
  69. 69.
    Mauger JF, Lichtenstein AH, Ausman LM, et al.: Effect of different forms of dietary hydrogenated fats on LDL particle size. Am J Clin Nutr 2003, 78:370–375.PubMedGoogle Scholar

Copyright information

© Current Science Inc 2005

Authors and Affiliations

  • Patty W. Siri
    • 1
  • Ronald M. Krauss
    • 1
  1. 1.Department of Atherosclerosis ResearchChildren’s Hospital Oakland Research InstituteOaklandUSA

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