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Current Atherosclerosis Reports

, Volume 6, Issue 3, pp 180–185 | Cite as

Antidiabetic actions of estrogen: Insight from human and genetic mouse models

  • Jean-Francois Louet
  • Cedric LeMay
  • Franck Mauvais-Jarvis
Article

Abstract

There is increasing evidence both in humans and rodents linking the endogenous estrogen 17β-estradiol (E2) to the maintenance of glucose homeostasis. Postmenopausal women develop visceral obesity and insulin resistance and are at increased risk for type 2 diabetes mellitus, but hormone replacement therapy leads to a reduction in the incidence of diabetes. In various spontaneous rodent models of type 2 diabetes, female rodents are protected against hyperglycemia unless they are ovariectomized, and E2 perfusion reverses diabetes in male rodents. Finally, the study of transgenic mice and mice with genetic alteration of E2 secretion or E2 action has shed light on the antidiabetic properties of E2 at a tissue-specific level. Thus, E2 secretion and action in rodents seems to be implicated 1) in adipose tissue biology and the prevention of obesity, 2) in the stimulation of liver fatty acid metabolism and suppression of hepatic glucose production, and 3) in the protection of pancreatic β-cell function/survival and insulin secretion in conditions of oxidative stress.

Keywords

Insulin Resistance Hepatic Glucose Production Antidiabetic Action Conjugate Equine Estrogen Muscle Glucose Uptake 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Current Science Inc 2004

Authors and Affiliations

  • Jean-Francois Louet
    • 1
  • Cedric LeMay
    • 1
  • Franck Mauvais-Jarvis
    • 1
  1. 1.Department of Medicine, Division of Diabetes, Endocrinology & MetabolismBaylor College of MedicineHoustonUSA

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