Current Atherosclerosis Reports

, Volume 5, Issue 2, pp 150–154 | Cite as

Coronary arterial remodeling: From bench to bedside

  • Paul Schoenhagen
  • Steven E. Nissen
  • E. Murat Tuzcu


Coronary arterial remodeling describes changes of vessel size at the site of atherosclerotic lesions. Positive remodeling (expansion) of early lesions maintains lumen size despite plaque accumulation. In contrast, negative remodeling (shrinkage) contributes to luminal stenosis independent of plaque accumulation. Because of these adaptive changes, plaque progression/regression is not closely reflected in luminal size. Histologic studies have demonstrated that the pathophysiologic role of arterial remodeling is more complex than a mere compensatory process. Surprisingly, there is a consistent association between positive arterial remodeling, local inflammatory response, and plaque vulnerability. In vivo tomographic imaging techniques, in particular intravascular ultrasound, and potentially computed tomography and magnetic resonance imaging, allow the observation of remodeling in clinical settings. The integration of basic knowledge about arterial remodeling with clinical observations from in vivo imaging could lead to a better understanding of plaque progression, regression, and vulnerability and may eventually have implications for disease prevention.


Acute Coronary Syndrome Plaque Rupture Intravascular Ultrasound Plaque Burden Vulnerable Plaque 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Current Science Inc. 2003

Authors and Affiliations

  • Paul Schoenhagen
    • 1
  • Steven E. Nissen
    • 1
  • E. Murat Tuzcu
    • 1
  1. 1.The Cleveland Clinic FoundationClevelandUSA

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