Current Atherosclerosis Reports

, Volume 4, Issue 1, pp 26–33 | Cite as

Goals of statin therapy: Three viewpoints

  • Gilbert R. Thompson
  • Christopher J. Packard
  • Neil J. Stone


The “lipid hypothesis” is now universally recognized as a law. Few issues in medicine are as completely resolved as the question of whether reducing serum cholesterol increases longevity. However, there are a few questions that remain, and the most important uncertainty is to what extent cholesterol should be reduced. The medical community, in partnership with government and industry, has contributed many excellent trials demonstrating the effects in patients with elevated cholesterol (above the mean). Where should our goal of therapy be? Until data is available from several large, ongoing trials, we do not have a final answer. We asked three investigators, Drs. Gilbert Thompson, Christopher Packard, and Neil Stone, who have all been integrally involved in the accumulation of our present database, to argue three different possible answers.


Statin Pravastatin Statin Therapy Scandinavian Simvastatin Survival Study Coronary Heart Disease 
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Copyright information

© Current Science Inc 2002

Authors and Affiliations

  • Gilbert R. Thompson
    • 1
  • Christopher J. Packard
    • 2
  • Neil J. Stone
    • 3
  1. 1.Metabolic Medicine, Imperial College School of MedicineHammersmith HospitalLondonUnited Kingdom
  2. 2.Department of Pathological Biochemistry, Glasgow Royal Infirmary, 4th FloorUniversity BlockGlasgowUnited Kingdom
  3. 3.Northwestern University School of MedicineChicagoUSA

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