Current Atherosclerosis Reports

, Volume 4, Issue 3, pp 193–198 | Cite as

Genetic determinants of diabetes and atherosclerosis

  • Braxton D. Mitchell
  • Ikhide G. Imumorin
Article

Abstract

Common risk factors for type 2 diabetes and cardiovascular disease are suspected because of the higher than expected prevalence of cardiovascular disease in individuals with newly diagnosed type 2 diabetes and in nondiabetic individuals with impaired glucose tolerance. Some of these risk factors may be genetic in origin. The risk of diabetes and cardiovascular disease may be linked through common pathways, including insulin resistance and/or inflammation. In this review, we describe the rationale for proposing these as common mechanisms affecting both diabetes and cardiovascular risk, and we then summarize the available evidence suggesting that common genes within these pathways have pleiotropic effects influencing susceptibility to both diseases.

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Copyright information

© Current Science Inc 2002

Authors and Affiliations

  • Braxton D. Mitchell
    • 1
  • Ikhide G. Imumorin
    • 1
  1. 1.Division of Endocrinology, Diabetes, and NutritionUniversity of Maryland School of MedicineBaltimoreUSA

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