Current Atherosclerosis Reports

, Volume 3, Issue 3, pp 252–259

Atherogenesis and the arginine hypothesis

  • John P. Cooke
  • Roberta K. Oka

Abstract

In patients who have elevated levels of plasma ADMA, a relative deficiency of L-arginine has been found to contribute to the pathophysiology of athersclerosis, causing vasoconstriction, and accelerating atherogenesis. This finding—that there is a relative deficiency of L-arginine in atherosclerotic disease—is a breakthrough that will open new avenues of therapy.

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Copyright information

© Current Science Inc 2001

Authors and Affiliations

  • John P. Cooke
    • 1
  • Roberta K. Oka
    • 1
  1. 1.Section of Vascular MedicineStanford University School of MedicineStanfordUSA

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