Current Atherosclerosis Reports

, Volume 3, Issue 6, pp 462–470

Recent findings in the study of postprandial lipemia

  • Elizabeth J. Parks


The study of postprandial metabolism is in the early stages compared with other areas of atherosclerosis research. Recent advances in postprandial research have included improvements in methodology and the investigation of factors that modulate the lipemic response to a meal. Enough studies have now been performed that normal ranges have been identified for blood triacylglycerol (TAG) concentrations that occur after a healthy patient consumes a standardized-mixed meal or a high-fat shake designed to elicit lipemia. Typical postprandial concentrations of other metabolites, such as apolipoproteins B48 and B100 or gastrointestinal hormones (eg, cholecystokinin), have not been studied sufficiently to be able to qualify what represents a standard postprandial response. The method of data analysis is also a key point to consider. Data from children are now becoming available, and the specific effects of ethnicity have just begun to be explored. New areas of study include the effects of different fatty acids (monosaturates or polyunsaturates), the sources of chylomicron lipids (dietary TAG and cholesterol versus that newly synthesized in the body), and the effects of alcoholic beverages consumed with the meal. Variables that can also affect the results of a meal test are under investigation. These include the type of food that is consumed the day before the meal test, the time of day the test is performed, and the palatability of the food. Given solid evidence that delayed postprandial lipemia is an independent risk factor for coronary heart disease, future scientific investigation in the area of post-prandial metabolism is likely to yield discoveries that will significantly contribute to advancements in disease treatment.


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References and Recommended Reading

  1. 1.
    Participants: Symposium of postprandial lipoprotein metabolism. Atherosclerosis 1998, 141:S1-S113.Google Scholar
  2. 2.
    Patsch JR, Miesenbock G, Hopferwieser T, et al.: Relations of triglyceride metabolism and coronary artery disease: studies in the postprandial state. Arterioscler Thromb 1992, 12:1336–1345.PubMedGoogle Scholar
  3. 3.
    Roche HM, Gibney MJ: The impact of postprandial lipemia in accelerating atherothrombosis. J Cardiol Risk 2000, 7:317–324.Google Scholar
  4. 4.
    Sniderman AD: Postprandial hypertriglyceridemia(s): time to enlarge our pathophysiologic perspective. Eur J Clin Invest 2000, 30:935–937.PubMedCrossRefGoogle Scholar
  5. 5.
    Mjos OD, Rao SN, Bjoru L, et al.: A longitudinal study of the biological variability of plasma lipoproteins in healthy young adults. Atherosclerosis 1979, 34:75–81.PubMedCrossRefGoogle Scholar
  6. 6.
    Miller M: Triglyceride as a risk factor, epidemiology. Lipids 1999, 34:S267.Google Scholar
  7. 7.
    Phillips C, Murugasu G, Owens D, et al.: Improved metabolic control reduces the number of postprandial apolipoprotein B-48-containing particles in type 2 diabetes. Atherosclerosis 2000, 148:283–291.PubMedCrossRefGoogle Scholar
  8. 8.
    Couch SC, Isasi CR, Karmally W, et al.: Predictors of postprandial triacylglycerol response in children: the Columbia University Biomarkers Study. Am J Clin Nutr 2000, 72:1119–1127.PubMedGoogle Scholar
  9. 9.
    Friday KE, Srinivasan SR, Elkasabany A, et al.: Black-white differences in postprandial triglyceride response and postheparin lipoprotein lipase and hepatic triglyceride lipase among young men. Metabolism Clin Exp 1999, 48:749–754.Google Scholar
  10. 10.
    Mathews JN, Altman DG, Camppbell MJ, Rotston P: Analysis of serial measurements in medical research. BMJ 1990, 300:230–235.Google Scholar
  11. 11.
    Dawson JD: Comparing treatment groups on the basis of slopes, areas-under-the-curve, and other summary measures. Drug Info J 1994, 28:723–732.Google Scholar
  12. 12.
    Bourdon I, Olson B, Backus R, et al.: Beans, as a source of dietary fiber, increase cholecystokinin and apolipoprotein B48 response to test meals in men. J Nutr 2001, 131:1485–1490.PubMedGoogle Scholar
  13. 13.
    Tinker LF, Parks EJ, Behr SR, et al.: N-3 fatty acid supplementation in moderately hypertriglyceridemic adults changes postprandial lipid and apolipoprotein B responses to a standardized test meal. J Nutr 1999, 129:1126–1134.PubMedGoogle Scholar
  14. 14.
    McLaughlin J, Luca MG, Jones MN, et al.: Fatty acid chain length determines cholecystokinin secretion and effect on human gastric motility. Gastroeneterology 1999, 116:46–53.CrossRefGoogle Scholar
  15. 15.
    Hopman WP, Jansen JB, Rosenbusch G, Lamers CB: Effect of equimolar amounts of long chain triglycerides and medium chain triglycerides on plasma cholecystokinin and gall bladder contraction. Am J Clin Nutr 1984, 39:356–369.PubMedGoogle Scholar
  16. 16.
    Isaacs PE, Ladas MD, Forgacs IC, et al.: Comparison of effects of ingested medium- and long-chain triglyceride on gallbladder volume and release of cholecystokinin and other gut peptides. Dig Dis Sci 1987, 32:481–486.PubMedCrossRefGoogle Scholar
  17. 17.
    Gill JM, Hardman AE: Postprandial lipemia: effects of exercise and restriction of energy intake compared. Am J Clin Nutr 2000, 71:465–471.PubMedGoogle Scholar
  18. 18.
    Murphy MH, Nevill AM, Hardman AE: Different patterns of brisk walking are equally effective in decreasing postprandial lipaemia. Int J Obes Related Metab Disord 2000, 24:1303–1309.CrossRefGoogle Scholar
  19. 19.
    Wolever TM, Jenkins DJ, Ocana AM, et al.: Second-meal effect: low-glycemic-index foods eaten at dinner improve subsequent breakfast glycemic response. Am J Clin Nutr 1988, 48:1041–1047.PubMedGoogle Scholar
  20. 20.
    Pedersen A, Marckmann P, Sandstrom B: Postprandial lipoprotein, glucose and insulin responses after two consecutive meals containing rapeseed oil, sunflower oil or palm oil with or without glucose at the first meal. Br J Nutr 1999, 82:97–104.PubMedGoogle Scholar
  21. 21.
    Fielding BA, Reid G, Grady M, et al.: Ethanol with a mixed meal increases postprandial triacylglycerol but decreases postprandial non-esterified fatty acid concentrations. Br J Nutr 2000, 83:597–604.PubMedCrossRefGoogle Scholar
  22. 22.
    Yang LY, Kuksis A, Myher JJ, Steiner G: Contribution of de novo fatty acid synthesis to very low density lipoprotein triacyglycerols: evidence from mass isotopomer distribution analysis of fatty acids synthesized from 2H6 ethanol. J Lipid Res 1996, 37:262–274.PubMedGoogle Scholar
  23. 23.
    Siler SQ, Neese RA, Parks EJ, Hellerstein MK: VLDL-triglyceride production after alcohol ingestion, studied using [2-13C1] glycerol. J Lipid Res 1998, 39:2319–2328.PubMedGoogle Scholar
  24. 24.
    Pownall HJ: Dietary ethanol is associated with reduced lipolysis of intestinally derived lipoproteins. J Lipid Res 1994, 35:2105–2113.PubMedGoogle Scholar
  25. 25.
    Goldberg CS, Tall AR, Krumholz S: Acute inhibition of hepatic lipase and increase in plasma lipoproteins after alcohol intake. J Lipid Res 1984, 25:714–720.PubMedGoogle Scholar
  26. 26.
    Sane T, Nikkila EA, Taskinen MR, et al.: Accelerated turnover of very low density lipoprotein triglycerides in chronic alcohol users: a possible mechanism for the up-regulation of high density lipoprotein by ethanol. Atherosclerosis 1984, 53:185–193.PubMedCrossRefGoogle Scholar
  27. 27.
    van der Gaag MS, Sierksma A, Schaafsma G, et al.: Moderate alcohol consumption and changes in postprandial lipoproteins of premenopausal and postmenopausal women: a diet-controlled, randomized intervention study. J Womens Health & Gender-Based Med 2000, 9:607–616.CrossRefGoogle Scholar
  28. 28.
    El-Sayed MS, AL-Bayatti MF: Effects of alcohol ingestion following exercise on postprandial lipemia. Alcohol 2001, 23:15–21.PubMedCrossRefGoogle Scholar
  29. 29.
    Mattes RD: Oral exposure to butter, but not fat replacers elevates postprandial triacyglycerol concentration in humans. J Nutr 2001, 131:1491–1496.PubMedGoogle Scholar
  30. 30.
    Hadjadj S, Paul JL, Meyer L, et al.: Delayed changes in post-prandial lipid in young normolipidemic men after a nocturnal vitamin A oral fat load test. J Nutr 1999, 129:1649–1655.PubMedGoogle Scholar
  31. 31.
    McNamara JR, Shah PK, Nakajima K, et al.: Remnant lipoprotein cholesterol and triglyceride reference ranges from the Framingham Heart Study. Clin Chem 1998, 44:1224–1232.PubMedGoogle Scholar
  32. 32.
    Marcoux C, Hopkins PN, Wang T, et al.: Remnant-like particle cholesterol and triglyceride levels of hypertriglyceridemic patients in the fed and fasted state. J Lipid Res 2000, 11:1428–1436.Google Scholar
  33. 33.
    Devaraj S, Vega G, Lange R, et al.: Remnant-like particle cholesterol levels in patients with dysbetalipoproteinemia or coronary artery disease. Am J Med 1998, 104:445–450.PubMedCrossRefGoogle Scholar
  34. 34.
    Diraison F, Pachiaudi C, Beylot M: Measuring lipogenesis and cholesterol synthesis in humans with deuterated water: use of simple gas chromatographic/mass spectrometric techniques. J Mass Spectrometry 1997, 32:81–86.CrossRefGoogle Scholar
  35. 35.
    Guo ZK, Cella LK, Baum C, et al.: De novo lipogenesis in adipose tissue of lean and obese women: application of deuterated water and isotope ratio mass spectrometry. Int J Obes 2000, 24:932–937.CrossRefGoogle Scholar
  36. 36.
    Chascione C, Elwyn DH, Davila M, et al.: Effect of carbohydrate intake on de novo lipogenesis in human adipose tissue. Am J Physiol 1987, 253:E664-E669.PubMedGoogle Scholar
  37. 37.
    Yankah V, Diraison F, Beylot M, Jones PJ: Contribution of hepatic versus extra-hepatic lipogenesis to adipose tissue triglycerides. FASEB J 2001, 15:A996.Google Scholar
  38. 38.
    Hudgins LC, Hellerstein MK, Seidman CE, et al.: Relationship between carbohydrate-induced hypertriglyceridemia and fatty acid synthesis in lean and obese subjects. J Lipid Res 2000, 41:595–604.PubMedGoogle Scholar
  39. 39.
    Marques-Lopes I, Ansorena D, Astiasaran I, et al.: Postprandial de novo lipogenesis and metabolic changes induced by a high-carbohydrate, low-fat meal in lean and overweight men. Am J Clin Nutr 2001, 73:253–261.PubMedGoogle Scholar
  40. 40.
    Vidon C, Boucher P, Cachefo A, et al.: Effects of isoenergetic high-carbohydrate compared with high-fat diets on human choleserol synthesis and expression of key regulatory genes of cholesterol metabolism. Am J Clin Nutr 2001, 73:878–884.PubMedGoogle Scholar
  41. 41.
    Beaumier-Gallon G, Lanfranchi J, Vergnes MF, et al.: Method for simultaneous measurements of traces of heptadeuterated cholesterol and cholesterol by gas chromatography-mass spectrometry: application in humans. J Chrom 1998, 718:23–32.CrossRefGoogle Scholar
  42. 42.
    Beaumier-Gallon G, Dubois C, Portugal H, Lairon D: Postprandial studies on dietary cholesterol in human subjects using stable isotopes and gas chromatographymass spectrometry analysis. Atherosclerosis 1998, 141(suppl 1):S81-S85.PubMedCrossRefGoogle Scholar
  43. 43.
    Beaumier-Gallon G, Dubois C, Senft M, et al.: Dietary cholesterol is secreted in intestinally derived chylomicrons during several subsequent postprandial phases in healthy humans. Am J Clin Nutr 2001, 73:870–877.PubMedGoogle Scholar
  44. 44.
    Hellerstein MK, Neese RA: Mass isotopomer distribution analysis at eight years: theoretical, analytic, and experimental considerations. Am J Physiol 1999, 276:E1146-E1170.PubMedGoogle Scholar
  45. 45.
    Shaffer EA, Small DM: Biliary lipid secretion in cholesterol gall stones disease: the effect of cholecystectomy and obesity. J Clin Invest 1977, 59:828–840.PubMedCrossRefGoogle Scholar

Copyright information

© Current Science Inc 2001

Authors and Affiliations

  • Elizabeth J. Parks
    • 1
  1. 1.Department of Food Science and NutritionUniversity of Minnesota, Twin CitiesSt. PaulUSA

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