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Current Atherosclerosis Reports

, Volume 2, Issue 1, pp 36–46 | Cite as

Mechanism of action of niacin on lipoprotein metabolism

  • Vaijinath S. Kamanna
  • Moti L. Kashyap
Article

Abstract

It is generally accepted that the increased concentrations of apolipoprotein (apo) B containing very low-density lipoproteins (VLDL) and low-density lipoproteins (LDL), and decreased levels of apo AI containing high-density lipoproteins (HDL) are correlated to atherosclerotic cardiovascular disease. Current evidence indicates that the post-translational apo-B degradative processes regulate the hepatic assembly and secretion of VLDL and the subsequent generation of LDL particles. The availability of triglycerides (TG) for the addition to apo B during intracellular processing appears to play a central role in targeting apo B for either intracellular degradation or assembly and secretion as VLDL particles. Based on the availability of TG, the liver secretes either dense TG-poor VLDL2 or large TG-rich VLDL1 particles, and these particles serve as precursors for the formation of more buoyant or small, dense LDL particles by lipid transfer protein- and hepatic lipase-mediated processes. HDLs are a heterogenous class of lipoproteins, and apo AI (the major protein of HDL) participates in reverse cholesterol transport, a process by which excess cholesterol is eliminated. Recent studies indicate that HDL particles containing only apo A-I (LPA-I) are more effective in reverse cholesterol transport and more anti-atherogenic than HDL particles containing both apo A-I and apo A-II (LPA-I+A-II).

Keywords

Niacin Reverse Cholesterol Transport ALLN Nonstatin Drug VLDL Assembly 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Current Science Inc 2000

Authors and Affiliations

  • Vaijinath S. Kamanna
    • 1
  • Moti L. Kashyap
    • 2
  1. 1.Department of Medicine (Gerontology)University of CaliforniaIrvineUSA
  2. 2.Department of Veterans Affairs Healthcare SystemCholesterol Research CenterLong BeachUSA

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