Current Allergy and Asthma Reports

, Volume 6, Issue 5, pp 437–443

The role of immune tolerance in asthma pathogenesis

  • Kurt G. Tournoy
  • Sharen Provoost
  • Chris Van Hove
  • Guy Joos
Article

DOI: 10.1007/s11882-996-0018-3

Cite this article as:
Tournoy, K.G., Provoost, S., Van Hove, C. et al. Curr Allergy Asthma Rep (2006) 6: 437. doi:10.1007/s11882-996-0018-3

Abstract

Immune-mediated tolerance encompasses a wide spectrum of mechanisms that can prevent unnecessary and potentially harmful inflammatory responses. An increasing number of scientific publications provide proof for the concept that an impairment of immune-tolerance mechanisms might be causally related to the development of unwanted Th2-driven, allergen-induced airway diseases. In this review, we discuss immune tolerance and the evidence supporting its role in asthma pathogenesis.

Copyright information

© Current Science Inc 2006

Authors and Affiliations

  • Kurt G. Tournoy
    • 1
  • Sharen Provoost
  • Chris Van Hove
  • Guy Joos
  1. 1.Department of Respiratory DiseasesGhent University HospitalGentBelgium

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