The role of immune tolerance in asthma pathogenesis
- Cite this article as:
- Tournoy, K.G., Provoost, S., Van Hove, C. et al. Curr Allergy Asthma Rep (2006) 6: 437. doi:10.1007/s11882-996-0018-3
- 72 Downloads
Immune-mediated tolerance encompasses a wide spectrum of mechanisms that can prevent unnecessary and potentially harmful inflammatory responses. An increasing number of scientific publications provide proof for the concept that an impairment of immune-tolerance mechanisms might be causally related to the development of unwanted Th2-driven, allergen-induced airway diseases. In this review, we discuss immune tolerance and the evidence supporting its role in asthma pathogenesis.