Thymic stromal lymphopoietin: A potential therapeutic target for allergy and asthma
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Thymic stromal lymphopoietin (TSLP) is an interleukin (IL)-7-like cytokine that has recently been implicated as central to the microenvironment and is permissive for the immunologic cascade that initiates and propagates allergic immune responses. In humans, TSLP is produced predominantly by epithelial cells and activated mast cells, and stimulates myeloid dendritic cells (mDC), which uniquely express the heterodimeric TSLP receptor. TSLP-activated mDC can promote naïve CD4+ T cells to differentiate into a Th2 phenotype and can promote the expansion of CD4+ Th2 memory cells. Recent evidence implicates TSLP as playing a pivotal role in the pathobiology of allergic asthma and atopic dermatitis. The potential for TSLP to provide a new therapeutic target for the treatment of allergic disorders is compelling, and elucidating the mechanisms that regulate TSLP expression and the effects of TSLP on orchestrating the immune response toward a Th2 phenotype should facilitate this quest.
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References and Recommended Reading
- 21.Yoo J, Omori M, Gyarmati D, et al.: Spontaneous atopic dermatitis in mice expressing an inducible thymic stromal lymphopoietin transgene specifically in the skin. J Exp Med 2005, 202:541–549. This article demonstrates the role of TSLP in the pathogenesis of atopic dermatitis in a murine model.PubMedCrossRefGoogle Scholar
- 22.Li M, Messaddeq N, Teletin M, et al.: Retinoid X receptor ablation in adult mouse keratinocytes generates an atopic dermatitis triggered by thymic stromal lymphopoietin. Proc Natl Acad Sci U S A 2005, 102:14795–14800. This article demonstrates the role of TSLP in the pathogenesis of atopic dermatitis in a murine model.PubMedCrossRefGoogle Scholar
- 23.Ying S, O’Connor B, Ratoff J, et al.: Thymic stromal lymphopoietin expression is increased in asthmatic airways and correlates with expression of Th2-attracting chemokines and disease severity. J Immunol 2005, 174:8183–8190. This article provides the first association of TSLP expression in the airways of asthmatic patients.PubMedGoogle Scholar