Chlorhexidine Allergy: On the Rise and Often Overlooked
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Purpose of Review
In recent years, the risk of allergy to chlorhexidine is increasingly recognised. In this review, we discuss why the allergy is so easily overlooked and point out several preventative initiatives that can minimise the risk of both chlorhexidine sensitisation and allergy development and accidental re-exposure in patients with chlorhexidine allergy. Testing for chlorhexidine allergy is also discussed.
Numerous reports have been published from many different specialties. Symptoms range from mild skin symptoms to life-threatening anaphylaxis. Testing for chlorhexidine allergy is based on skin testing and in vitro testing. Recently, it was found that both skin prick testing and specific IgE have high sensitivities and specificities.
This review gives an overview of chlorhexidine allergy with a special focus on preventative initiatives and testing.
KeywordsChlorhexidine Chlorhexidine allergy Skin testing Specific IgE Perioperative allergy Allergy testing
There are no external sources of funding.
Compliance with Ethical Standards
Conflicts of Interest
GBE Jemec has received honoraria from AbbVie, Chemocentryx, Coloplast, Incyte, Inflarx, Novartis, Pierre Fabre and UCB for participation on advisory boards, and grants from Abbvie, Leo Pharma, Janssen-Cilag, Regeneron, Sanofi, Astra-Zeneca and Novartis for participation as an investigator, and received speaker honoraria from AbbVie, Boehringer-Ingelheim, Galderma and MSD. He has also received unrestricted departmental grants from Abbvie, Leo Pharma and Novartis. LHG is an adjudication committee member for Merck, New Jersey US and Novo Nordisk, Denmark. MSO has no conflicts of interest.
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance
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